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Site-Specific Diagnostic Evaluation of Hard Biological Tissues Using Solitary Waves

Yang, Jinkyu and Sangiorgio, Sophia N. and Borkowski, Sean L. and Ebramzadeh, Edward and Daraio, Chiara (2013) Site-Specific Diagnostic Evaluation of Hard Biological Tissues Using Solitary Waves. In: Mechanics of Biological Systems and Materials. Vol.4. Springer , Cham, pp. 185-189. ISBN 978-3-319-00776-2.

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We perform site-specific diagnostic evaluation of hard biological tissues via highly nonlinear solitary waves. Solitary waves are compact-supported tunable pulses with extremely high energy density, which can be efficiently formed in a chain of ordered granular particles defined as 1D granular crystals. We transmit a single pulse of solitary waves into specific areas of artificial biological systems via direct mechanical contact with a granular crystal sensor. We then record the solitary waves backscattered from a targeted bone area to assess its mechanical stiffness. By taking advantage of the coupling between nonlinear granular media and biological systems, we demonstrate that reflected solitary waves are highly sensitive to site-specific mechanical properties of hard biological tissues. The efficacy of the diagnostic approach is investigated by comparing the stiffness measurements with nominal elastic moduli of polyurethane foams that mimic osteoporotic bone. We also perform numerical investigations via a discrete element (DE) model, simulating propagation and attenuation of solitary waves at the interfaces. The site-specific evaluation technique via solitary waves has the potential for clinical applications, such as assisting appropriate intraoperative decision during joint replacement or spinal surgery for better surgical outcome.

Item Type:Book Section
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URLURL TypeDescription ReadCube access
Daraio, Chiara0000-0001-5296-4440
Additional Information:© 2014 The Society for Experimental Mechanics, Inc. First Online: 21 July 2013.
Subject Keywords:Bone diagnostics; NDE; Solitary waves; Granular crystals
Record Number:CaltechAUTHORS:20170705-153021095
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78777
Deposited By: Tony Diaz
Deposited On:06 Jul 2017 22:50
Last Modified:29 Apr 2020 22:10

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