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Correlation of Multi-scale Modeling and Experimental Results for the Elastic Modulus of Trabecular Bone

Hamed, Elham and Novitskaya, Ekaterina and Li, Jun and Setters, Alexander and Lee, Woowon and McKittrick, Joanna and Jasiuk, Iwona (2013) Correlation of Multi-scale Modeling and Experimental Results for the Elastic Modulus of Trabecular Bone. In: Mechanics of Biological Systems and Materials. Vol.4. Springer , Cham, pp. 59-65. ISBN 978-3-319-00776-2. https://resolver.caltech.edu/CaltechAUTHORS:20170705-160214354

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Abstract

Trabecular bone is a porous nanocomposite material with a hierarchical structure. In this study, a multi-scale modeling approach, addressing scales spanning from the nanometer (collagen-mineral) to mesoscale (trabecular bone) levels, was developed to determine the elastic moduli of trabecular bone. Then, the predicted modeling results were compared with experimental data obtained by compression testing of bovine femur trabecular bone samples loaded in two different directions; parallel to the femur neck axis and perpendicular to that. Optical microscopy, scanning electron microscopy and micro-computed tomography techniques were employed to characterize the structure and composition of the samples at different length scales and provide the inputs needed for the modeling. To obtain more insights on the structure of bone, especially on the interaction of its main constituents (collagen and mineral phases), trabecular bone samples were deproteinized or demineralized and, afterwards, tested mechanically in compression. The experimental observations were used, in turn, to fine-tune the multi-scale model of bone as an interpenetrating composite material. Good agreement was found between the theoretical and experimental results for elastic moduli of untreated, deproteinized, and demineralized trabecular bones.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://dx.doi.org/10.1007/978-3-319-00777-9_8DOIArticle
http://rdcu.be/tZcdPublisherFree ReadCube access
Additional Information:© 2014 The Society for Experimental Mechanics, Inc. First Online: 21 July 2013. This work was supported by NSF Ceramics Program Grant 1006931 (JM) and the CMMI Program Grant 09–27909 (IJ).
Funders:
Funding AgencyGrant Number
NSFDMR-1006931
NSFCMMI-0927909
Subject Keywords:Trabecular bone; Elastic moduli; Multi-scale modeling; Compression test; Demineralization; Deproteinization
Record Number:CaltechAUTHORS:20170705-160214354
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170705-160214354
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78780
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 Jul 2017 22:40
Last Modified:29 Apr 2020 22:09

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