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3-D Electrochemical Impedance Spectroscopy Mapping of Arteries to Detect Metabolically Active but Angiographically Invisible Atherosclerotic Lesions

Packard, René R. Sevag and Luo, Yuan and Abiri, Parinaz and Jen, Nelson and Aksoy, Olcay and Suh, William M. and Tai, Yu-Chong and Hsiai, Tzung K. (2017) 3-D Electrochemical Impedance Spectroscopy Mapping of Arteries to Detect Metabolically Active but Angiographically Invisible Atherosclerotic Lesions. Theranostics, 7 (9). pp. 2431-2442. ISSN 1838-7640. PMCID PMC5525747. https://resolver.caltech.edu/CaltechAUTHORS:20170706-155341835

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Abstract

We designed a novel 6-point electrochemical impedance spectroscopy (EIS) sensor with 15 combinations of permutations for the 3-D mapping and detection of metabolically active atherosclerotic lesions. Two rows of 3 stretchable electrodes circumferentially separated by 120° were mounted on an inflatable balloon for intravascular deployment and endoluminal interrogation. The configuration and 15 permutations of 2-point EIS electrodes allowed for deep arterial penetration via alternating current (AC) to detect varying degrees of lipid burden with distinct impedance profiles (Ω). By virtue of the distinctive impedimetric signature of metabolically active atherosclerotic lesions, a detailed impedance map was acquired, with the 15 EIS permutations uncovering early stages of disease characterized by fatty streak lipid accumulation in the New Zealand White rabbit model of atherosclerosis. Both the equivalent circuit and statistical analyses corroborated the 3-D EIS permutations to detect small, angiographically invisible, lipid-rich lesions, with translational implications for early atherosclerotic disease detection and prevention of acute coronary syndromes or strokes.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.7150/thno.19184DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525747/PubMed CentralArticle
ORCID:
AuthorORCID
Packard, René R. Sevag0000-0002-8520-5843
Tai, Yu-Chong0000-0001-8529-106X
Hsiai, Tzung K.0000-0003-1734-0792
Additional Information:© 2017 Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). Received: 2017.01.14; Accepted: 2017.04.18; Published: 2017.06.22. This study was supported by National Institutes of Health grants HL118650 (T.K.H., Y.C.T.), HL083015 (T.K.H.), HL111437 (T.K.H., Y.C.T.), and HL129727 (T.K.H.), the UCLA STAR program (R.R.S.P.), and American Heart Association Scientist Development Grant 16SDG30910007 (R.R.S.P.). The authors have declared that no competing interest exists.
Funders:
Funding AgencyGrant Number
NIHHL118650
NIHHL083015
NIHHL111437
NIHHL129727
UCLA STAR ProgramUNSPECIFIED
American Heart Association16SDG30910007
Subject Keywords:Electrochemical Impedance Spectroscopy, 3-D Mapping, Atherosclerosis
Issue or Number:9
PubMed Central ID:PMC5525747
Record Number:CaltechAUTHORS:20170706-155341835
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170706-155341835
Official Citation:Packard RRS, Luo Y, Abiri P, Jen N, Aksoy O, Suh WM, Tai YC, Hsiai TK. 3-D Electrochemical Impedance Spectroscopy Mapping of Arteries to Detect Metabolically Active but Angiographically Invisible Atherosclerotic Lesions. Theranostics 2017; 7(9):2431-2442. doi:10.7150/thno.19184. Available from http://www.thno.org/v07p2431.htm
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78824
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:07 Jul 2017 18:18
Last Modified:26 Nov 2019 00:07

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