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HIV Entry and Its Inhibition

Chan, David C. and Kim, Peter S. (1998) HIV Entry and Its Inhibition. Cell, 93 (5). pp. 681-684. ISSN 0092-8674. doi:10.1016/S0092-8674(00)81430-0.

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The human immunodeficiency virus type 1 (HIV-1) is an enveloped virus, and its envelope protein complex controls the key process of viral entry. This envelope protein determines viral tropism and facilitates the membrane fusion process that allows invasion of the viral genome. The envelope protein can also promote the fusion of infected cells with uninfected neighboring cells, a phenomenon called syncytium formation that is readily observed in cultured cells and may be responsible for some of the cytopathic effects of advanced HIV infection. Here we review recent insights in HIV envelope protein structure and function and present our current understanding of the entry process. We also review how these findings lead to new approaches for inhibiting HIV entry and may provide insights into the design of better HIV vaccines.

Item Type:Article
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Chan, David C.0000-0002-0191-2154
Additional Information:© 1998 Cell Press.
Issue or Number:5
Record Number:CaltechAUTHORS:20170707-123731974
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Official Citation:David C Chan, Peter S Kim, HIV Entry and Its Inhibition, Cell, Volume 93, Issue 5, 1998, Pages 681-684, ISSN 0092-8674, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78856
Deposited By: Tony Diaz
Deposited On:07 Jul 2017 20:09
Last Modified:15 Nov 2021 17:43

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