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Mitochondria: Dynamic Organelles in Disease, Aging, and Development

Chan, David C. (2006) Mitochondria: Dynamic Organelles in Disease, Aging, and Development. Cell, 125 (7). pp. 1241-1252. ISSN 0092-8674. doi:10.1016/j.cell.2006.06.010.

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Mitochondria are the primary energy-generating system in most eukaryotic cells. Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis. Given these well-established functions, it might be expected that mitochondrial dysfunction would give rise to a simple and predictable set of defects in all tissues. However, mitochondrial dysfunction has pleiotropic effects in multicellular organisms. Clearly, much about the basic biology of mitochondria remains to be understood. Here we discuss recent work that suggests that the dynamics (fusion and fission) of these organelles is important in development and disease.

Item Type:Article
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Chan, David C.0000-0002-0191-2154
Additional Information:© 2006 Elsevier Inc. Available online 29 June 2006. I am grateful to Hsiuchen Chen for helpful discussions.
Issue or Number:7
Record Number:CaltechAUTHORS:20170707-131920686
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Official Citation:David C. Chan, Mitochondria: Dynamic Organelles in Disease, Aging, and Development, Cell, Volume 125, Issue 7, 2006, Pages 1241-1252, ISSN 0092-8674, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78861
Deposited By: Tony Diaz
Deposited On:07 Jul 2017 20:27
Last Modified:15 Nov 2021 17:43

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