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Critical dependence of neurons on mitochondrial dynamics

Chen, Hsiuchen and Chan, David C. (2006) Critical dependence of neurons on mitochondrial dynamics. Current Opinion in Cell Biology, 18 (4). pp. 453-459. ISSN 0955-0674. doi:10.1016/

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The selective disruption of certain cell types — notably neurons — in diseases involving mitochondrial dysfunction is thought to reflect the high-energy requirements of these cells, but few details are known. Recent studies have provided clues to the cellular basis of this mitochondrial requirement. Mitochondria are regionally organized within some nerve cells, with higher accumulations in the soma, the hillock, the nodes of Ranvier and the nerve terminal. In the synaptic region, mitochondria regulate calcium and ATP levels, thereby maintaining synaptic transmission and structure. Defects in mitochondrial dynamics can cause deficits in mitochondrial respiration, morphology and motility. Moreover, mutations in the mitochondrial fusion genes Mitofusin-2 and OPA1 lead to the peripheral neuropathy Charcot-Marie-Tooth type 2A and dominant optic atrophy. Perhaps it is the strict spatial and functional requirements for mitochondria in neurons that cause defects in mitochondrial fusion to manifest primarily as neurodegenerative diseases.

Item Type:Article
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Chan, David C.0000-0002-0191-2154
Additional Information:© 2006 Elsevier Ltd. Available online 14 June 2006. Work in D. Chan's laboratory is funded by the NIH (GM062967), the Muscular Dystrophy Association, and the United Mitochondrial Disease Foundation. D. Chan is a Bren Scholar.
Funding AgencyGrant Number
Muscular Dystrophy AssociationUNSPECIFIED
United Mitochondrial Disease FoundationUNSPECIFIED
Bren FoundationUNSPECIFIED
Issue or Number:4
Record Number:CaltechAUTHORS:20170707-134400692
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Official Citation:Hsiuchen Chen, David C Chan, Critical dependence of neurons on mitochondrial dynamics, Current Opinion in Cell Biology, Volume 18, Issue 4, 2006, Pages 453-459, ISSN 0955-0674, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78864
Deposited By: Tony Diaz
Deposited On:07 Jul 2017 21:00
Last Modified:15 Nov 2021 17:43

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