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Molecular mechanism of mitochondrial membrane fusion

Griffin, Erik E. and Detmer, Scott A. and Chan, David C. (2006) Molecular mechanism of mitochondrial membrane fusion. Biochimica et Biophysica Acta, 1763 (5-6). pp. 482-489. ISSN 0167-4889. doi:10.1016/j.bbamcr.2006.02.003.

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Mitochondrial fusion requires coordinated fusion of the outer and inner membranes. This process leads to exchange of contents, controls the shape of mitochondria, and is important for mitochondrial function. Two types of mitochondrial GTPases are essential for mitochondrial fusion. On the outer membrane, the fuzzy onions/mitofusin proteins form complexes in trans that mediate homotypic physical interactions between adjacent mitochondria and are likely directly involved in outer membrane fusion. Associated with the inner membrane, the OPA1 dynamin-family GTPase maintains membrane structure and is a good candidate for mediating inner membrane fusion. In yeast, Ugo1p binds to both of these GTPases to form a fusion complex, although a related protein has yet to be found in mammals. An understanding of the molecular mechanism of fusion may have implications for Charcot–Marie–Tooth subtype 2A and autosomal dominant optic atrophy, neurodegenerative diseases caused by mutations in Mfn2 and OPA1.

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Chan, David C.0000-0002-0191-2154
Additional Information:© 2006 Elsevier B.V. Received 16 January 2006, Accepted 14 February 2006, Available online 9 March 2006. Work in D. Chan's laboratory is funded by the NIH (GM062967), the Muscular Dystrophy Association, and the United Mitochondrial Disease Foundation. D. Chan is a Bren Scholar.
Funding AgencyGrant Number
Muscular Dystrophy AssociationUNSPECIFIED
United Mitochondrial Disease FoundationUNSPECIFIED
Subject Keywords:Membrane fusion; Mitochondrial dynamics; Mitochondrial fusion; GTPase; Organelles
Issue or Number:5-6
Record Number:CaltechAUTHORS:20170707-145340571
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Official Citation:Erik E. Griffin, Scott A. Detmer, David C. Chan, Molecular mechanism of mitochondrial membrane fusion, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1763, Issues 5–6, May–June 2006, Pages 482-489, ISSN 0167-4889, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78870
Deposited By: Ruth Sustaita
Deposited On:10 Jul 2017 17:29
Last Modified:15 Nov 2021 17:43

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