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Mitochondrial Dynamics in Mammals

Chen, Hsiuchen and Chan, David C. (2004) Mitochondrial Dynamics in Mammals. Current Topics in Developmental Biology, 59 . pp. 119-144. ISSN 0070-2153. doi:10.1016/S0070-2153(04)59005-1.

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This chapter discusses the role of mitochondria dynamics in mammalian mitochondrial morphology, mitochondrial function, disease, embryogenesis, and apoptosis. It defines mitochondria as static, kidney bean-shaped organelles that have the mundane chore of providing energy for the cell. The mitochondrial population is, in fact, dynamic, and the hundreds of mitochondria in a cell can have a range of morphologies, including small spheres, long tubules, and interconnected tubules. This morphological plasticity is based on the ability of mitochondria to undergo both organellar fusion and fission. The chapter reviews the current molecular understanding of mitochondrial fusion and fission. Several observations indicate that mitochondrial dynamics plays a significant role in vertebrate cells. The time-lapse observations of mammalian cells reveal frequent and constant cycles of mitochondrial fusion and fission. The identification of molecules involved in the fusion and fission pathways has allowed an assessment of their relative roles in controlling mitochondrial morphology. The chapter also discusses the importance of mitochondrial dynamics in human physiology.

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Chan, David C.0000-0002-0191-2154
Additional Information:© 2004 Elsevier Inc. Available online 4 March 2004.
Record Number:CaltechAUTHORS:20170710-085130148
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Official Citation:Hsiuchen Chen, David C Chan, Mitochondrial Dynamics in Mammals, Current Topics in Developmental Biology, Volume 59, 2004, Pages 119-144, ISSN 0070-2153, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78884
Deposited By: Tony Diaz
Deposited On:10 Jul 2017 16:51
Last Modified:15 Nov 2021 17:43

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