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Perspectives on the Functional Characterization and In Vitro Maintenance of Circulating Tumor Cells

Williams, Anthony and Harouaka, Ramdane and Zheng, Siyang and Albanese, Chris and Schlegel, Richard and Tai, Yu-Chong and Datar, Ram H. and Cote, Richard J. (2016) Perspectives on the Functional Characterization and In Vitro Maintenance of Circulating Tumor Cells. In: Circulating Tumor Cells. Springer , New York, NY, pp. 215-231. ISBN 978-1-4939-3361-7.

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Circulating tumor cells (CTCs) that detach and migrate from primary tumors are implicated in the metastatic spread of cancer. The identification of CTCs in peripheral blood samples has been associated with poor survival outcomes in various cancer types. As a readily accessible source of tumor tissue there is a vast potential to develop CTCs as a biomarker to advance cancer diagnosis, prognosis and the development of novel and targeted therapies. The fact that CTCs occur as extremely rare events in whole blood presents a technical challenge for characterization, requiring enrichment techniques that are both highly sensitive and sufficiently specific. The culture and expansion of CTCs is desirable as a means of yielding a population suitable for comprehensive functional characterization and drug testing. Reports of successful in vitro culture of CTCs are rare, but various approaches have been attempted and significant progress has been made. The development of protocols for reliable and efficient culture of viable CTCs will advance our biological understanding of cancer metastasis and facilitate the development of personalized therapies.

Item Type:Book Section
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Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2016 Springer Science+Business Media New York. First Online: 04 February 2016.
Subject Keywords:Circulating tumor cells (CTCs); CTC Culture; CTC functional characterization; Personalized therapy; Chemoresponse
Record Number:CaltechAUTHORS:20170718-111456398
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:79157
Deposited By: Tony Diaz
Deposited On:18 Jul 2017 18:24
Last Modified:03 Oct 2019 18:16

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