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Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease

Chu, Hiutung (2017) Host gene–microbiome interactions: molecular mechanisms in inflammatory bowel disease. Genome Medicine, 9 (1). Art. No. 69. ISSN 1756-994X. PMCID PMC5525272. https://resolver.caltech.edu/CaltechAUTHORS:20170725-131533882

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Abstract

Recent studies have identified links between host genetic variants and microbial recognition of the microbiome. Defects in host–microbiome interactions in individuals harboring inflammatory bowel disease risk alleles may result in imbalances of the microbial community, impaired pathogen clearance, and failure to sense beneficial commensal microbes. These findings highlight the importance of maintaining bi-directional communication at the mucosal interface during intestinal homeostasis.


Item Type:Article
Related URLs:
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https://doi.org/10.1186/s13073-017-0459-4DOIArticle
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0459-4PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525272/PubMed CentralArticle
Additional Information:© 2017 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Published: 24 July 2017. The author would like to thank Gil Sharon for thoughtful discussions and critical reading of the manuscript. The author is supported by NIH grant K99DK110534. The author declares that she has no competing interests.
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Funding AgencyGrant Number
NIHK99DK110534
Issue or Number:1
PubMed Central ID:PMC5525272
Record Number:CaltechAUTHORS:20170725-131533882
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170725-131533882
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:79342
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:25 Jul 2017 20:29
Last Modified:03 Oct 2019 18:19

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