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Electronic Signature of DNA Nucleotides via Transverse Transport

Zwolak, Michael and Di Ventra, Massimiliano (2005) Electronic Signature of DNA Nucleotides via Transverse Transport. Nano Letters, 5 (3). pp. 421-424. ISSN 1530-6984. doi:10.1021/nl048289w.

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We report theoretical studies of charge transport in single-stranded DNA in the direction perpendicular to the backbone axis. We find that, if the electrodes which sandwich the DNA have the appropriate spatial width, each nucleotide carries a unique signature due to the different electronic and chemical structure of the four bases. This signature is independent of the nearest-neighbor nucleotides. Furthermore, except for the nucleotides with guanine and cytosine bases, we find that the difference in conductance of the nucleotides is large for most orientations of the bases with respect to the electrodes. By exploiting these differences it may be possible to sequence single-stranded DNA by scanning its length with conducting probes.

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Additional Information:© 2005 American Chemical Society. Received October 19, 2004. Publication Date (Web): February 12, 2005. One of us (M.D.) is indebted to Len Feldman and Mike Ramsey for their suggestion to work on this topic and for useful discussions. We acknowledge partial support from the NSF Grant DMR-01-33075 and the National Human Genome Research Institute. One of us (M.Z.) also acknowledges support from an NSF Graduate Fellowship.
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National Human Genome Research InstituteUNSPECIFIED
NSF Graduate Research FellowshipUNSPECIFIED
Issue or Number:3
Record Number:CaltechAUTHORS:20170726-100202274
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Official Citation:Electronic Signature of DNA Nucleotides via Transverse Transport Michael Zwolak and Massimiliano Di Ventra. Nano Letters 2005 5 (3), 421-424 DOI: 10.1021/nl048289w
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:79406
Deposited By: Tony Diaz
Deposited On:26 Jul 2017 22:37
Last Modified:15 Nov 2021 17:48

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