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Enzyme-Free Nucleic Acid Dynamical Systems

Srinivas, Niranjan and Parkin, James and Seelig, Georg and Winfree, Erik and Soloveichik, David (2017) Enzyme-Free Nucleic Acid Dynamical Systems. Science, 358 (6369). Art. No. eaal2052. ISSN 0036-8075.

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An important goal of synthetic biology is to create biochemical control systems with the desired characteristics from scratch. Srinivas et al. describe the creation of a biochemical oscillator that requires no enzymes or evolved components, but rather is implemented through DNA molecules designed to function in strand displacement cascades. Furthermore, they created a compiler that could translate a formal chemical reaction network into the necessary DNA sequences that could function together to provide a specified dynamic behavior.

Item Type:Article
Related URLs:
URLURL TypeDescription Materials Paper
Parkin, James0000-0002-4058-2338
Winfree, Erik0000-0002-5899-7523
Soloveichik, David0000-0002-2585-4120
Additional Information:© 2017 American Association for the Advancement of Science. Received 25 October 2016; accepted 25 October 2017. We thank L. Qian for help with initial experiments and technical training; C. G. Evans for supporting the development of Piperine; A. Phillips for assistance with Visual DSD; and L. Cardelli, C. Geary, C. T. Martin, N. A. Pierce, P. W. K. Rothemund, S. L. Sparvath, B. Wolfe, F. Dannenberg, and D. Y. Zhang for helpful discussions. This work was supported by the NSF grants 0728703, 0829805, 0832824, 1317694, 1117143, and 1618895; Office of Naval Research award N00014-16-1-2139; the Gordon and Betty Moore Foundation’s Programmable Molecular Technology Initiative; and National Institute of General Medical Sciences Systems Biology Center grant P50 GM081879. Data presented in the paper are archived in the Supplementary Materials.
Funding AgencyGrant Number
Office of Naval Research (ONR)N00014-16-1-2139
Gordon and Betty Moore FoundationUNSPECIFIED
NIHP50 GM081879
Issue or Number:6369
Record Number:CaltechAUTHORS:20170731-085900027
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Official Citation:Enzyme-free nucleic acid dynamical systems BY NIRANJAN SRINIVAS, JAMES PARKIN, GEORG SEELIG, ERIK WINFREE, DAVID SOLOVEICHIK Science 15 Dec 2017: Vol. 358, Issue 6369, eaal2052 DOI: 10.1126/science.aal2052
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:79580
Deposited By: Tony Diaz
Deposited On:01 Aug 2017 20:05
Last Modified:21 Feb 2020 21:41

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