Thubagere, Anupama J. and Li, Wei and Johnson, Robert F. and Chen, Zibo and Doroudi, Shayan and Lee, Yae Lim and Izatt, Gregory and Wittman, Sarah and Srinivas, Niranjan and Woods, Damien and Winfree, Erik and Qian, Lulu (2017) A cargo-sorting DNA robot. Science, 357 (6356). Art. No. eaan6558. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20170731-174213645
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Abstract
Single-stranded DNA robots can move over the surface of a DNA origami sheet and sort molecular cargoes. Thubagere et al. developed a simple algorithm for recognizing two types of molecular cargoes and their drop-off destinations on the surface (see the Perspective by Reif). The DNA robot, which has three modular functional domains, repeatedly picks up the two types of molecules and then places them at their target destinations. No additional power is required because the DNA robot does this by random walking across the origami surface.
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| Additional Information: | © 2017 American Association for the Advancement of Science. We thank R. Murray, P. Rothemund, C. Thachuk, P. Yin, and R. Jungmann for discussions and suggestions. Z.C., S.D., Y.L.L., G.I., and S.W. were supported by Caltech Summer Undergraduate Research Fellowships. N.S., D.W., and E.W. were supported by an NSF Expedition in Computing (0832824). A.J.T. was supported by an NSF grant (1351081). W.L. was supported by an NSF Expedition in Computing (1317694). R.F.J. was supported by an NSF Graduate Research Fellowship. L.Q. was supported by a Career Award at the Scientific Interface from the Burroughs Wellcome Fund (1010684) and a Faculty Early Career Development Award from the NSF (1351081). All data are reported in the main text and the supplementary materials. | ||||||||||||||
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| Record Number: | CaltechAUTHORS:20170731-174213645 | ||||||||||||||
| Persistent URL: | http://resolver.caltech.edu/CaltechAUTHORS:20170731-174213645 | ||||||||||||||
| Official Citation: | A cargo-sorting DNA robot BY ANUPAMA J. THUBAGERE, WEI LI, ROBERT F. JOHNSON, ZIBO CHEN, SHAYAN DOROUDI, YAE LIM LEE, GREGORY IZATT, SARAH WITTMAN, NIRANJAN SRINIVAS, DAMIEN WOODS, ERIK WINFREE, LULU QIAN SCIENCE15 SEP 2017 | ||||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||
| ID Code: | 79651 | ||||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||||
| Deposited By: | Joy Painter | ||||||||||||||
| Deposited On: | 14 Sep 2017 17:50 | ||||||||||||||
| Last Modified: | 14 Sep 2017 17:50 |
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