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A cargo-sorting DNA robot

Thubagere, Anupama J. and Li, Wei and Johnson, Robert F. and Chen, Zibo and Doroudi, Shayan and Lee, Yae Lim and Izatt, Gregory and Wittman, Sarah and Srinivas, Niranjan and Woods, Damien and Winfree, Erik and Qian, Lulu (2017) A cargo-sorting DNA robot. Science, 357 (6356). Art. No. eaan6558. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20170731-174213645

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Abstract

Single-stranded DNA robots can move over the surface of a DNA origami sheet and sort molecular cargoes. Thubagere et al. developed a simple algorithm for recognizing two types of molecular cargoes and their drop-off destinations on the surface (see the Perspective by Reif). The DNA robot, which has three modular functional domains, repeatedly picks up the two types of molecules and then places them at their target destinations. No additional power is required because the DNA robot does this by random walking across the origami surface.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1126/science.aan6558DOIArticle
http://science.sciencemag.org/content/357/6356/eaan6558PublisherArticle
http://www.sciencemag.org/content/357/6356/eaan6558/suppl/DC1?_ga=2.81146197.339277655.1505410922-2046127699.1503951604PublisherSupplementary Materials
ORCID:
AuthorORCID
Winfree, Erik0000-0002-5899-7523
Additional Information:© 2017 American Association for the Advancement of Science. We thank R. Murray, P. Rothemund, C. Thachuk, P. Yin, and R. Jungmann for discussions and suggestions. Z.C., S.D., Y.L.L., G.I., and S.W. were supported by Caltech Summer Undergraduate Research Fellowships. N.S., D.W., and E.W. were supported by an NSF Expedition in Computing (0832824). A.J.T. was supported by an NSF grant (1351081). W.L. was supported by an NSF Expedition in Computing (1317694). R.F.J. was supported by an NSF Graduate Research Fellowship. L.Q. was supported by a Career Award at the Scientific Interface from the Burroughs Wellcome Fund (1010684) and a Faculty Early Career Development Award from the NSF (1351081). All data are reported in the main text and the supplementary materials.
Funders:
Funding AgencyGrant Number
Caltech Summer Undergraduate Research Fellowship (SURF)UNSPECIFIED
NSFCCF-0832824
NSFCCF-1351081
NSFCCF-1317694
NSF Graduate Research FellowshipUNSPECIFIED
Burroughs Wellcome Fund1010684
Record Number:CaltechAUTHORS:20170731-174213645
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20170731-174213645
Official Citation:A cargo-sorting DNA robot BY ANUPAMA J. THUBAGERE, WEI LI, ROBERT F. JOHNSON, ZIBO CHEN, SHAYAN DOROUDI, YAE LIM LEE, GREGORY IZATT, SARAH WITTMAN, NIRANJAN SRINIVAS, DAMIEN WOODS, ERIK WINFREE, LULU QIAN SCIENCE15 SEP 2017
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:79651
Collection:CaltechAUTHORS
Deposited By: Joy Painter
Deposited On:14 Sep 2017 17:50
Last Modified:14 Sep 2017 17:50

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