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Easily fabricated ion source for characterizing mixtures of organic compounds by direct analysis in real time mass spectrometry

Upton, Kathleen T. and Schilling, Katherine A. and Beauchamp, J. L. (2017) Easily fabricated ion source for characterizing mixtures of organic compounds by direct analysis in real time mass spectrometry. Analytical Methods, 9 (34). pp. 5065-5074. ISSN 1759-9660. http://resolver.caltech.edu/CaltechAUTHORS:20170801-093347646

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Abstract

The increasing use of atmospheric pressure mass spectrometry has led to the development of many ambient ionization sources, for which sampling versatility and low cost are desired features. One such recent ambient ionization method is direct analysis in real time mass spectrometry (DART-MS), which has proven to be well suited to the analysis of native samples of both simple and complex natures. We describe a home-built DART source (EZ-DART) with versatile sampling capabilities, low power requirements, and low assembly cost which can be easily interfaced to mass spectrometers equipped with an atmospheric pressure inlet. The operating temperature range (22–250 °C) enables the acquisition of both temperature programmed desorption-based DART mass spectra and the collection of multistep collision-induced dissociation (CID) mass spectra. We present here the validation of the EZ-DART source and a demonstration of its performance in a number of relevant applications. Additionally, we introduce the new DART application of reagent assisted desorption ionization (RADI) for the targeting of specific chemical functionality in complex organic mixtures through a host–guest chemical system.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1039/c7ay00971bDOIArticle
http://pubs.rsc.org/en/Content/ArticleLanding/2017/AY/C7AY00971BPublisherArticle
http://www.rsc.org/suppdata/c7/ay/c7ay00971b/c7ay00971b1.pdfPublisherSupplementary Information
ORCID:
AuthorORCID
Upton, Kathleen T.0000-0003-4292-7616
Beauchamp, J. L.0000-0001-8839-4822
Additional Information:© 2017 The Royal Society of Chemistry. The article was received on 13 Apr 2017, accepted on 20 Jul 2017 and first published on 21 Jul 2017. The research was funded by NSF award number CHE-1508825. The early part of this work was funded by NASA Astrobiology Institute, Titan as a Prebiotic Chemical System and the Keck Institute for Space Studies, Future Missions to Titan: Scientific and Engineering Challenges. K. T. U. acknowledges financial support from the Harriett Jenkins Pre-Doctoral Fellowship Program. The authors would like to thank Mike Uribe Productions for the EZ-DART photographs and the Caltech Glass Shop for assistance with manufacture of the EZ-DART source. There are no conflicts of interest to declare.
Group:Keck Institute for Space Studies
Funders:
Funding AgencyGrant Number
NSFCHE-1508825
NASA Predoctoral FellowshipUNSPECIFIED
Keck Institute for Space Studies (KISS)UNSPECIFIED
Record Number:CaltechAUTHORS:20170801-093347646
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20170801-093347646
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:79667
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:01 Aug 2017 17:05
Last Modified:26 Oct 2018 17:34

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