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Fast DNA Sequencing via Transverse Electronic Transport

Lagerqvist, Johan and Zwolak, Michael and Di Ventra, Massimiliano (2006) Fast DNA Sequencing via Transverse Electronic Transport. Nano Letters, 6 (4). pp. 779-782. ISSN 1530-6984. doi:10.1021/nl0601076.

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A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of single-stranded DNA while it translocates through a nanopore. Our estimates, based on the statistics of these distributions, reveal that sequencing of an entire human genome could be done with very high accuracy in a matter of hours without parallelization, that is, orders of magnitude faster than present techniques. The practical implementation of our approach would represent a substantial advancement in our ability to study, predict, and cure diseases from the perspective of the genetic makeup of each individual.

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Additional Information:© 2006 American Chemical Society. Received 17 January 2006. Published online 11 March 2006. Published in print 1 April 2006. We gratefully acknowledge discussions with M. Ramsey and T. Schindler. This research is supported by the NIH-National Human Genome Research Institute (J.L. and M.D.) and by the National Science Foundation through its Graduate Fellowship program (M.Z.).
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National Human Genome Research InstituteUNSPECIFIED
NSF Graduate Research FellowshipUNSPECIFIED
Issue or Number:4
Record Number:CaltechAUTHORS:20170807-082812681
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Official Citation:Fast DNA Sequencing via Transverse Electronic Transport Johan Lagerqvist, Michael Zwolak, and Massimiliano Di Ventra Nano Letters 2006 6 (4), 779-782 DOI: 10.1021/nl0601076
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:79834
Deposited By: Ruth Sustaita
Deposited On:07 Aug 2017 23:04
Last Modified:15 Nov 2021 17:50

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