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Four alpha ganglion cell types in mouse retina: Function, structure, and molecular signatures

Barnes, Steven and Krieger, Brenna and Qiao, Mu and Rousso, David L. and Sanes, Joshua R. and Meister, Markus (2017) Four alpha ganglion cell types in mouse retina: Function, structure, and molecular signatures. PLOS ONE, 12 (7). Art. No. e0180091. ISSN 1932-6203. https://resolver.caltech.edu/CaltechAUTHORS:20170807-132930354

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Abstract

The retina communicates with the brain using ≥30 parallel channels, each carried by axons of distinct types of retinal ganglion cells. In every mammalian retina one finds so-called "alpha" ganglion cells (αRGCs), identified by their large cell bodies, stout axons, wide and mono-stratified dendritic fields, and high levels of neurofilament protein. In the mouse, three αRGC types have been described based on responses to light steps: On-sustained, Off-sustained, and Off-transient. Here we employed a transgenic mouse line that labels αRGCs in the live retina, allowing systematic targeted recordings. We characterize the three known types and identify a fourth, with On-transient responses. All four αRGC types share basic aspects of visual signaling, including a large receptive field center, a weak antagonistic surround, and absence of any direction selectivity. They also share a distinctive waveform of the action potential, faster than that of other RGC types. Morphologically, they differ in the level of dendritic stratification within the IPL, which accounts for their response properties. Molecularly, each type has a distinct signature. A comparison across mammals suggests a common theme, in which four large-bodied ganglion cell types split the visual signal into four channels arranged symmetrically with respect to polarity and kinetics.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1371/journal.pone.0180091DOIArticle
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180091PublisherArticle
ORCID:
AuthorORCID
Meister, Markus0000-0003-2136-6506
Additional Information:© 2017 Krieger et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Editor: Steven Barnes, Dalhousie University, CANADA Received: November 11, 2016. Accepted: June 11, 2017. Published: July 28, 2017. Thanks to Max Joesch for contributing neural recording data. Funding: Supported by NIH grants 1U01NS090562 to M.M., NS029169 and EY022073 to J.R.S, and EY025119 to D.L.R. Author Contributions Conceptualization: BK MQ JS MM. Data curation: BK MQ DR MM. Formal analysis: BK MQ DR JS MM. Funding acquisition: DR JS MM. Investigation: BK MQ DR. Methodology: BK DR JS MM. Project administration: JS MM. Software: BK DR MM. Supervision: JS MM. Validation: JS MM. Visualization: BK MM. Writing – original draft: BK MM. Writing – review & editing: BK MQ DR JS MM.
Funders:
Funding AgencyGrant Number
NIH1U01NS090562
NIHNS029169
NIHEY022073
NIHEY025119
Issue or Number:7
Record Number:CaltechAUTHORS:20170807-132930354
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170807-132930354
Official Citation:Krieger B, Qiao M, Rousso DL, Sanes JR, MeisterM (2017) Four alpha ganglion cell types in mouse retina: Function, structure, and molecular signatures. PLoS ONE 12(7): e0180091. https://doi.org/10.1371/journal.pone.0180091
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:79848
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:07 Aug 2017 21:20
Last Modified:03 Oct 2019 18:24

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