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Selective recognition of bis-imidazoles by complementary bis-metal ion complexes

Mallik, Sanku and Johnson, Robert D. and Arnold, Frances H. (1993) Selective recognition of bis-imidazoles by complementary bis-metal ion complexes. Journal of the American Chemical Society, 115 (6). pp. 2518-2520. ISSN 0002-7863. doi:10.1021/ja00059a063.

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Metal ion complexes that bind protein surfaces at exposed coordinating ligands can be exploited in selective protein recognition. For example, immobilized metal-affinity chromatography (IMAC), a technique used extensively for protein purification, discriminates proteins based on the nature and multiplicity of surface-exposed ligands, usually the imidazole moiety of histidine. To design complexes capable of selectively recognizing an individual protein or other target molecule, the spatial distribution of metal ions can be matched to the distribution of coordinating ligands on the target molecule. A similar proposal, when used as the basis for template polymerization in the presence of the target molecule, yielded solid, Cu^(2+) -containing polymers that could discriminate bis-imidazole "protein analogs" so similar that they could not be separated by reverse-phase HPLC. The "rationally designed" model system reported here demonstrates that receptor complexes containing as few as two properly-positioned metal ions can selectively recognize target molecules with a complementary spatial distribution of metal-coordinating ligands. Complexes such as these may have applications as receptors for biological molecules that are characterized by unique patterns of surface coordinating ligands.

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Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 1993 American Chemical Society. Received November 23, 1992. This research is supported by the Whitaker Foundation, the Office of Naval Research (N00014-92-J-1178), and the National Science Foundation (BCS-9108502). F.H.A. gratefully acknowledges a National Science Foundation PYI award and a fellowship from the David and Lucile Packard Foundation.
Funding AgencyGrant Number
Whitaker FoundationUNSPECIFIED
Office of Naval Research (ONR)N00014-92-J-1178
David and Lucile Packard FoundationUNSPECIFIED
Issue or Number:6
Record Number:CaltechAUTHORS:20170808-131101814
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Official Citation:Selective recognition of bis-imidazoles by complementary bis-metal ion complexes Sanku Mallik, Robert D. Johnson, and Frances H. Arnold Journal of the American Chemical Society 1993 115 (6), 2518-2520 DOI: 10.1021/ja00059a063
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:79938
Deposited By: Tony Diaz
Deposited On:09 Aug 2017 19:03
Last Modified:15 Nov 2021 17:51

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