A Caltech Library Service

Quantitative photoacoustic elastography of Young’s modulus in humans

Hai, Pengfei and Zhou, Yong and Gong, Lei and Wang, Lihong V. (2017) Quantitative photoacoustic elastography of Young’s modulus in humans. In: Photons Plus Ultrasound: Imaging and Sensing 2017. Proceedings of SPIE. No.10064. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 100640B. ISBN 9781510605701.

[img] PDF - Published Version
See Usage Policy.


Use this Persistent URL to link to this item:


Elastography can noninvasively map the elasticity distribution of biological tissue, which is often altered in pathological states. In this work, we report quantitative photoacoustic elastography (QPAE), capable of measuring Young’s modulus of human tissue in vivo. By combining photoacoustic elastography with a stress sensor having known stress-strain behavior, QPAE can simultaneously measure strain and stress, from which Young’s modulus is calculated. We first applied QPAE to quantify the Young’s modulus of tissue-mimicking agar phantoms with different concentrations. The measured values fitted well with both the empirical expectations based on the agar concentrations and those measured in independent standard compression tests. We then demonstrated the feasibility of QPAE by measuring the Young’s modulus of human skeletal muscle in vivo. The data showed a linear relationship between muscle stiffness and loading. The results proved that QPAE can noninvasively quantify the absolute elasticity of biological tissue, thus enabling longitudinal imaging of tissue elasticity. QPAE can be exploited for both preclinical biomechanics studies and clinical applications.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2017 SPIE. We thank Alejandro Garcia-Uribe, Chiye Li, and Guo Li for their help in the project. We also thank Professor James Ballard for a close reading of this paper. This work was sponsored by the March of Dimes Foundation Grant No. 22FY14486 and the US National Institutes of Health grant Nos. DP1 EB016986 (NIH Director’s Pioneer Award), R01 CA186567 (NIH Director’s Transformative Research Award), and S10 RR026922. L. V. Wang has a financial interest in Microphotoacoustics, Inc., which, however, did not support this work.
Funding AgencyGrant Number
March of Dimes Foundation22FY14486
NIHDP1 EB016986
NIHR01 CA186567
NIHS10 RR026922
Series Name:Proceedings of SPIE
Issue or Number:10064
Record Number:CaltechAUTHORS:20170810-084558232
Persistent URL:
Official Citation:Pengfei Hai ; Yong Zhou ; Lei Gong and Lihong V. Wang " Quantitative photoacoustic elastography of Young’s modulus in humans ", Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100640B (March 3, 2017); doi:10.1117/12.2252790;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:80058
Deposited By: Tony Diaz
Deposited On:10 Aug 2017 16:34
Last Modified:03 Oct 2019 18:27

Repository Staff Only: item control page