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Going Deeper: Biomolecular Tools for Acoustic and Magnetic Imaging and Control of Cellular Function

Piraner, Dan I. and Farhadi, Arash and Davis, Hunter C. and Wu, Di and Maresca, David and Szablowski, Jerzy O. and Shapiro, Mikhail G. (2017) Going Deeper: Biomolecular Tools for Acoustic and Magnetic Imaging and Control of Cellular Function. Biochemistry, 56 (39). pp. 5202-5209. ISSN 0006-2960. http://resolver.caltech.edu/CaltechAUTHORS:20170814-132937862

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Abstract

Most cellular phenomena of interest to mammalian biology occur within the context of living tissues and organisms. However, today’s most advanced tools for observing and manipulating cellular function, based on fluorescent or light-controlled proteins, work best in cultured cells, transparent model species, or small, surgically accessed anatomical regions. Their reach into deep tissues and larger animals is limited by photon scattering. To overcome this limitation, we must design biochemical tools that interface with more penetrant forms of energy. For example, sound waves and magnetic fields easily permeate most biological tissues, allowing the formation of images and delivery of energy for actuation. These capabilities are widely used in clinical techniques such as diagnostic ultrasound, magnetic resonance imaging, focused ultrasound ablation, and magnetic particle hyperthermia. Each of these modalities offers spatial and temporal precision that could be used to study a multitude of cellular processes in vivo. However, connecting these techniques to cellular functions such as gene expression, proliferation, migration, and signaling requires the development of new biochemical tools that can interact with sound waves and magnetic fields as optogenetic tools interact with photons. Here, we discuss the exciting challenges this poses for biomolecular engineering and provide examples of recent advances pointing the way to greater depth in in vivo cell biology.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://dx.doi.org/10.1021/acs.biochem.7b00443DOIArticle
http://pubs.acs.org/doi/abs/10.1021/acs.biochem.7b00443PublisherArticle
ORCID:
AuthorORCID
Farhadi, Arash0000-0001-9137-8559
Maresca, David0000-0002-4921-6406
Shapiro, Mikhail G.0000-0002-0291-4215
Additional Information:© 2017 American Chemical Society. Received: May 8, 2017; Revised: June 24, 2017; Published: August 7, 2017. Special Issue: Seeing Into Cells Related work in the Shapiro laboratory is also supported by the Heritage Medical Research Institute, the National Institutes of Health, the Defense Advanced Research Projects Agency, the Jacobs Institute for Molecular Engineering in Medicine, the Caltech Center for Environmental Microbial Interactions, the Human Frontiers Science Program, the Burroughs Wellcome Fund, the Pew Scholarship in the Biomedical Sciences, the Sontag Foundation, and the Packard Fellowship for Science and Engineering. D.M. is supported by the Human Frontiers Science Program Cross Disciplinary Postdoctoral Fellowship (Award No. LT000637/2016). A.F. is supported by the Natural Sciences and Engineering Research Council of Canada PGSD. We thank members of the Shapiro Laboratory for helpful discussions. The authors declare no competing financial interest.
Group:Heritage Medical Research Institute, Caltech Center for Environmental Microbial Interactions (CEMI)
Funders:
Funding AgencyGrant Number
Heritage Medical Research InstituteUNSPECIFIED
NIHUNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Jacobs Institute for Molecular Engineering for MedicineUNSPECIFIED
Caltech Center for Environmental Microbial Interactions (CEMI)UNSPECIFIED
Human Frontier Science ProgramLT000637/2016
Burroughs Wellcome FundUNSPECIFIED
Pew Charitable TrustUNSPECIFIED
Sontag FoundationUNSPECIFIED
David and Lucile Packard FoundationUNSPECIFIED
Natural Sciences and Engineering Research Council of Canada (NSERC)UNSPECIFIED
Record Number:CaltechAUTHORS:20170814-132937862
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20170814-132937862
Official Citation:Going Deeper: Biomolecular Tools for Acoustic and Magnetic Imaging and Control of Cellular Function Dan I. Piraner, Arash Farhadi, Hunter C. Davis, Di Wu, David Maresca, Jerzy O. Szablowski, and Mikhail G. Shapiro Biochemistry 2017 56 (39), 5202-5209 DOI: 10.1021/acs.biochem.7b00443
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:80363
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:14 Aug 2017 21:02
Last Modified:08 Nov 2017 00:00

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