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Non-viral gene delivery systems

Davis, Mark E. (2002) Non-viral gene delivery systems. Current Opinion in Biotechnology, 13 (2). pp. 128-131. ISSN 0958-1669. doi:10.1016/S0958-1669(02)00294-X. https://resolver.caltech.edu/CaltechAUTHORS:20170822-154809325

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Abstract

Non-viral gene delivery systems have the potential to create viable pharmaceuticals from nucleic acids. These DNA delivery systems contain lipids and/or cationic polymers. In order for these systems to be developed into commercial products, several barriers must be overcome. These include obstacles in manufacturing, formulation and stability. In vivo, problems of extracellular non-specific interactions and intracellular trafficking to the nucleus are also encountered. Recent progress has been made in overcoming these issues.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/S0958-1669(02)00294-XDOIArticle
http://www.sciencedirect.com/science/article/pii/S095816690200294XPublisherArticle
ORCID:
AuthorORCID
Davis, Mark E.0000-0001-8294-1477
Additional Information:© 2002 Elsevier Science Ltd. Available online 8 May 2002.
Subject Keywords:Non-viral gene delivery; cationic polymers; lipids; intracellular trafficking; polyplex; lipoplex; stabilization
Issue or Number:2
DOI:10.1016/S0958-1669(02)00294-X
Record Number:CaltechAUTHORS:20170822-154809325
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170822-154809325
Official Citation:Mark E Davis, Non-viral gene delivery systems, Current Opinion in Biotechnology, Volume 13, Issue 2, 1 April 2002, Pages 128-131, ISSN 0958-1669, https://doi.org/10.1016/S0958-1669(02)00294-X. (http://www.sciencedirect.com/science/article/pii/S095816690200294X)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:80706
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 Aug 2017 17:05
Last Modified:15 Nov 2021 19:38

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