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Isolated poliovirus capsid protein VP1 induces a neutralizing response in rats

Chow, Marie and Baltimore, David (1982) Isolated poliovirus capsid protein VP1 induces a neutralizing response in rats. Proceedings of the National Academy of Sciences of the United States of America, 79 (23). pp. 7518-7521. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:CHOpnas82

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Abstract

Antibodies were raised in rats against the poliovirus type 1 capsid proteins, VP1, VP2, and VP3. Antibodies directed against VP1 from type 1 poliovirus (Mahoney) neutralized type 1 but not type 2 poliovirus. Antibodies raised against VP2 and VP3 failed to neutralize type 1 virus. Thus, VP1 appears to be a neutralizing antigen for poliovirus and in its denatured form presents to the immune system its neutralizing determinants.


Item Type:Article
ORCID:
AuthorORCID
Baltimore, David0000-0001-8723-8190
Additional Information:© 1982 by the National Academy of Sciences. Contributed by David Baltimore, August 30, 1982. This work was supported by a grant from the National Cancer Institute (CA14051 Core Grant to S.E. Luria) and Grant A108388 from the National Institute of Allergy and Infectious Diseases. M.C. is supported by an American Cancer Society Fellowship. D.B. is an American Cancer Society Research Professor. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
Subject Keywords:vaccine; immunoprecipitation
Record Number:CaltechAUTHORS:CHOpnas82
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:CHOpnas82
Alternative URL:http://dx.doi.org/10.1073/pnas.79.23.7518
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:8075
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Jul 2007
Last Modified:31 Oct 2017 18:10

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