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Optical focusing through biological tissue and tissue-mimicking phantoms up to 9.6 centimeters thick with digital optical phase conjugation

Shen, Yuecheng and Liu, Yan and Ma, Cheng and Wang, Lihong V. (2017) Optical focusing through biological tissue and tissue-mimicking phantoms up to 9.6 centimeters thick with digital optical phase conjugation. In: Adaptive Optics and Wavefront Control for Biological Systems III. Proceedings of SPIE. No.10073. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 100730G. ISBN 978-1-5106-0587-9. https://resolver.caltech.edu/CaltechAUTHORS:20170828-133137877

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Abstract

Optical phase conjugation (OPC) based wavefront shaping techniques focus light through or within scattering media, which is critically important for deep-tissue optical imaging, manipulation, and therapy. However, to date, the sample thicknesses used in wavefront shaping experiments have been limited to only a few millimeters or several transport mean free paths. Here, by using a long-coherence-length laser and an optimized digital OPC system that efficiently delivers light power, we focused 532 nm light through tissue-mimicking phantoms up to 9.6 cm thick, as well as through ex vivo chicken breast tissue up to 2.5 cm thick.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/12.2251052DOIArticle
https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10073/100730G/Optical-focusing-through-biological-tissue-and-tissue-mimicking-phantoms-up/10.1117/12.2251052.fullPublisherArticle
ORCID:
AuthorORCID
Shen, Yuecheng0000-0003-1990-8142
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2016 Society of Photo-Optical Instrumentation Engineers. Date Published: 21 February 2017. This work was sponsored in part by National Institute of Health grants DP1 EB016986 (NIH Director’s Pioneer Award) and R01 CA186567 (NIH Director’s Transformative Research Award).
Funders:
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 CA186567
Subject Keywords:Focusing light through scattering media, adaptive optics, wavefront shaping, optical phase conjugation, holographic interferometry, turbid media
Series Name:Proceedings of SPIE
Issue or Number:10073
Record Number:CaltechAUTHORS:20170828-133137877
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170828-133137877
Official Citation:Yuecheng Shen, Yan Liu, Cheng Ma, Lihong V. Wang, "Optical focusing through biological tissue and tissue-mimicking phantoms up to 9.6 centimeters thick with digital optical phase conjugation," Proc. SPIE 10073, Adaptive Optics and Wavefront Control for Biological Systems III, 100730G (21 February 2017)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:80852
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:28 Aug 2017 21:36
Last Modified:03 Oct 2019 18:35

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