Erie, Dorothy A. and Yager, Thomas D. and von Hippel, Peter H. (1992) The Single-Nucleotide Addition Cycle in Transcription: a Biophysical and Biochemical Perspective. Annual Review of Biophysics and Biomolecular Structure, 21 . pp. 379-415. ISSN 1056-8700. doi:10.1146/annurev.bb.21.060192.002115. https://resolver.caltech.edu/CaltechAUTHORS:20170905-090046586
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Abstract
It is useful to view the mechanisms and regulation of RNA transcript ion at different levels of resolution. Each view stresses different aspects of the structure and behavior of the DNA-dependent RNA polymerase, which is the enzyme that catalyzes specific gene transcription. We review here the mechanism of transcription as catalyzed by the RNA polymerase of Escherichia coli, which is by far the best understood member of this class of enzymes.
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| Additional Information: | © 1992 Annual Reviews. The experimental work from our laboratory on this topic, as well as the preparation of this review, has been supported, in part, by USPHS Research Grants GM-15792 and GM-29158 (to PHvH), by USPHS Individual Post-doctoral Fellowships GM-12915 (to DAE) and GM-10227 (to TDY), and by a grant to the Institute of Molecular Biology from the Lucille P. Markey Charitable Trust. PHvH is an American Cancer Society Research Professor of Chemistry. We are grateful to many colleagues here and elsewhere for providing preprints of unpublished work and for many discussions that have helped us to define and clarify the ideas presented in this review. | ||||||||||||||
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| Subject Keywords: | DNA transcription, RNA polymerase, RNA synthesis, regulation of transcription, transcription complexes | ||||||||||||||
| DOI: | 10.1146/annurev.bb.21.060192.002115 | ||||||||||||||
| Record Number: | CaltechAUTHORS:20170905-090046586 | ||||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20170905-090046586 | ||||||||||||||
| Official Citation: | The Single-Nucleotide Addition Cycle in Transcription: a Biophysical and Biochemical Perspective Dorothy A. Erie, Thomas D. Yager, Peter H. von Hippel Annual Review of Biophysics and Biomolecular Structure 1992 21:1, 379-415 | ||||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||
| ID Code: | 81126 | ||||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||||
| Deposited By: | Tony Diaz | ||||||||||||||
| Deposited On: | 05 Sep 2017 19:37 | ||||||||||||||
| Last Modified: | 15 Nov 2021 19:41 |
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