Catalytic asymmetric synthesis of alkylsilanes enabled by stereoconvergent nickel-catalyzed cross-coupling

Abstract

Over the years, the Fu group has demonstrated enantioconvergent cross-coupling reactions to be powerful tools for the synthesis of chiral mols. Most often, racemic secondary alkyl halide electrophiles are coupled with achiral nucleophiles to produce tertiary stereogenic centers in high yield and enantiomeric excess. In this talk, I will discuss our recent application of enantioconvergent nickel catalysis towards the prepn. of unactivated chiral alkyl silanes. The scope and limitations of this approach will be discussed, as well as some further applications of the enantioenriched products.