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Sensors using DNA charge transport

Barton, Jacqueline (2017) Sensors using DNA charge transport. In: 254th American Chemical Society National Meeting & Exposition, August 20-24, 2017, Washington, DC.

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Many expts. have now shown that double helical DNA can serve as a conduit for efficient charge transport over long mol. distances. This chem. is exquisitely sensitive to perturbations in the DNA base stack, such as arise with base mismatches, lesions, and protein binding. We describe how this chem. may be applied in constructing DNA-based electrochem. sensors for DNA-binding proteins and lesions. For example, using a two electrode multiplexed platform, human DNMT1 methyltransferase activity is easily detected from crude cell lysates. The effect of magnetic fields on DNA charge transport chem. has also been explored. These results point to sensitive mechanisms to consider in sensing magnetic fields.

Item Type:Conference or Workshop Item (Paper)
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Barton, Jacqueline0000-0001-9883-1600
Additional Information:© 2017 American Chemical Society.
Record Number:CaltechAUTHORS:20170913-103008005
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:81408
Deposited By: Tony Diaz
Deposited On:14 Sep 2017 02:36
Last Modified:03 Oct 2019 18:42

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