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DNA-mediated signaling among proteins with [4Fe4S] clusters

Barton, Jacqueline (2017) DNA-mediated signaling among proteins with [4Fe4S] clusters. In: 254th American Chemical Society National Meeting & Exposition, August 20-24, 2017, Washington, DC.

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Double helical DNA can serve as a conduit for efficient redox chem. over long mol. distances. We have now been exploring how this chem. may be used within the cell for long range signaling. Increasingly, [4Fe4S] clusters are being found in DNA-binding proteins involved in genome maintenance. These [4Fe4S] clusters, common redox cofactors, are assocd. not only with repair proteins but also DNA polymerases and primase. Studies are described to characterize DNA-mediated charge transport by these metalloproteins. Expts. indicate that this chem. is important in the context of oxidative damage and may provide a first step in how DNA repair proteins may localize in the vicinity of lesions. Moreover, DNA-mediated signaling among clusters may serve to coordinate the proteins involved in replication. This redox chem. at a distance, mediated by the DNA helix, thus offers a route for long range signaling among DNA-processing proteins across the genome.

Item Type:Conference or Workshop Item (Paper)
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Barton, Jacqueline0000-0001-9883-1600
Additional Information:© 2017 American Chemical Society.
Record Number:CaltechAUTHORS:20170913-104137841
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:81409
Deposited By: Tony Diaz
Deposited On:14 Sep 2017 02:35
Last Modified:03 Oct 2019 18:42

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