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A Circuit Node that Integrates Convergent Input from Neuromodulatory and Social Behavior-Promoting Neurons to Control Aggression in Drosophila

Watanabe, Kiichi and Chiu, Hui and Pfeiffer, Barret D. and Wong, Allan M. and Hoopfer, Eric D. and Rubin, Gerald M. and Anderson, David J. (2017) A Circuit Node that Integrates Convergent Input from Neuromodulatory and Social Behavior-Promoting Neurons to Control Aggression in Drosophila. Neuron, 95 (5). pp. 1112-1128. ISSN 0896-6273. http://resolver.caltech.edu/CaltechAUTHORS:20170914-102103491

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Abstract

Diffuse neuromodulatory systems such as norepinephrine (NE) control brain-wide states such as arousal, but whether they control complex social behaviors more specifically is not clear. Octopamine (OA), the insect homolog of NE, is known to promote both arousal and aggression. We have performed a systematic, unbiased screen to identify OA receptor-expressing neurons (OARNs) that control aggression in Drosophila. Our results uncover a tiny population of male-specific aSP2 neurons that mediate a specific influence of OA on aggression, independent of any effect on arousal. Unexpectedly, these neurons receive convergent input from OA neurons and P1 neurons, a population of FruM+ neurons that promotes male courtship behavior. Behavioral epistasis experiments suggest that aSP2 neurons may constitute an integration node at which OAergic neuromodulation can bias the output of P1 neurons to favor aggression over inter-male courtship. These results have potential implications for thinking about the role of related neuromodulatory systems in mammals.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.neuron.2017.08.017DOIArticle
http://www.sciencedirect.com/science/article/pii/S0896627317307328PublisherArticle
Additional Information:© 2017 Elsevier Inc. Received 6 March 2017, Revised 6 July 2017, Accepted 9 August 2017, Available online 30 August 2017. We thank H. Melkonian and J. Choi for fly stock maintenance, Y. Aso and H. Tanimoto for sharing fly lines, M. Gallio and Y. Chen for advice on GRASP experiments; members of the Anderson Lab fly group for advice, C. Chiu for lab management, G. Mancuso for administrative assistance, and P. Sternberg and B. Weissbourd for comments on the manuscript. This work was supported by NIDA Grant 2R01-DA031389, and a Human Frontier Science Program fellowship grant LT 00685/2006-L to K.W. D.J.A. is an Investigator of the Howard Hughes Medical Institute. K.W. dedicates this paper to the memory of his PhD advisor, the late Dr. Yoshiki Sasai.
Funders:
Funding AgencyGrant Number
NIH2R01-DA031389
Human Frontier Science ProgramLT 00685/2006-L
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
National Institute on Drug AbuseUNSPECIFIED
Record Number:CaltechAUTHORS:20170914-102103491
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20170914-102103491
Official Citation:Kiichi Watanabe, Hui Chiu, Barret D. Pfeiffer, Allan M. Wong, Eric D. Hoopfer, Gerald M. Rubin, David J. Anderson, A Circuit Node that Integrates Convergent Input from Neuromodulatory and Social Behavior-Promoting Neurons to Control Aggression in Drosophila, Neuron, Volume 95, Issue 5, 30 August 2017, Pages 1112-1128.e7, ISSN 0896-6273, https://doi.org/10.1016/j.neuron.2017.08.017. (http://www.sciencedirect.com/science/article/pii/S0896627317307328)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:81439
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:14 Sep 2017 17:49
Last Modified:14 Sep 2017 17:49

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