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The 4D nucleome project

Dekker, Job and Belmont, Andrew S. and Guttman, Mitchell and Leshyk, Victor O. and Lis, John T. and Lomvardas, Stavros and Mirny, Leonid A. and O’Shea, Clodagh C. and Park, Peter J. and Ren, Bing and Ritland Politz, Joan C. and Shendure, Jay and Zhong, Sheng (2017) The 4D nucleome project. Nature, 549 (7671). pp. 219-226. ISSN 0028-0836. PMCID PMC5617335. https://resolver.caltech.edu/CaltechAUTHORS:20170918-080921978

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Abstract

The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://dx.doi.org/10.1038/nature23884DOIArticle
http://www.nature.com/nature/journal/v549/n7671/full/nature23884.htmlPublisherArticle
http://rdcu.be/vXCWPublisherFree ReadCube access
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617335PubMed CentralArticle
https://doi.org/10.1101/103499DOIDiscussion Paper
ORCID:
AuthorORCID
Guttman, Mitchell0000-0003-4748-9352
Ritland Politz, Joan C.0000-0001-5229-0087
Additional Information:© 2017 Macmillan Publishers Limited. Received 27 January 2017 Accepted 27 July 2017 Published online 13 September 2017. Author Contributions All authors contributed to writing the manuscript. Author Information Reprints and permissions information is available at www.nature.com/reprints. The authors declare no competing financial interests. Readers are welcome to comment on the online version of the paper. Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Correspondence and requests for materials should be addressed to J.D. (job.dekker@umassmed.edu). Reviewer Information Nature thanks G. Almouzni, G. Cavalli and H. Stunnenberg for their contribution to the peer review of this work.
Subject Keywords:Epigenomics Gene regulation
Issue or Number:7671
PubMed Central ID:PMC5617335
Record Number:CaltechAUTHORS:20170918-080921978
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170918-080921978
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:81512
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:18 Sep 2017 21:01
Last Modified:03 Oct 2019 18:43

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