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DNA Cleavage by an α,3-Dehydrotoluene Precursor Conjugated to a Minor Groove Binding Element

Myers, Andrew G. and Parrish, Cynthia A. (1996) DNA Cleavage by an α,3-Dehydrotoluene Precursor Conjugated to a Minor Groove Binding Element. Bioconjugate Chemistry, 7 (3). pp. 322-331. ISSN 1043-1802. http://resolver.caltech.edu/CaltechAUTHORS:20170919-134911678

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Abstract

The (Z)-allene-ene-yne 10, a precursor to a reactive α,3-dehydrotoluene biradical, was covalently linked to a minor groove binding element, and the resultant conjugate (9) was shown to bind and cleave DNA with sequence selectivity.


Item Type:Article
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URLURL TypeDescription
https://doi.org/10.1021/bc9600170DOIArticle
http://pubs.acs.org/doi/abs/10.1021/bc9600170PublisherArticle
Additional Information:© 1996 American Chemical Society. Received November 21, 1995. Publication Date (Web): May 28, 1996. Generous support from the National Institutes of Health is gratefully acknowledged. C.A.P. acknowledges support from NIH Training Grant T32GM08501. We also thank Professor Peter B. Dervan and his research group, with special thanks to Dr. Milan Mrksich, for their many helpful suggestions throughout the course of this work.
Funders:
Funding AgencyGrant Number
NIH Predoctoral FellowshipT32GM08501
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Caltech Arnold and Mabel Beckman Laboratories of Chemical Synthesis9103
Record Number:CaltechAUTHORS:20170919-134911678
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20170919-134911678
Official Citation:DNA Cleavage by an α,3-Dehydrotoluene Precursor Conjugated to a Minor Groove Binding Element. Andrew G. Myers and Cynthia A. Parrish. Bioconjugate Chemistry 1996 7 (3), 322-331. DOI: 10.1021/bc9600170
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:81573
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:19 Sep 2017 20:56
Last Modified:19 Sep 2017 20:56

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