Myers, Andrew G. and Parrish, Cynthia A. (1996) DNA Cleavage by an α,3-Dehydrotoluene Precursor Conjugated to a Minor Groove Binding Element. Bioconjugate Chemistry, 7 (3). pp. 322-331. ISSN 1043-1802. http://resolver.caltech.edu/CaltechAUTHORS:20170919-134911678
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Abstract
The (Z)-allene-ene-yne 10, a precursor to a reactive α,3-dehydrotoluene biradical, was covalently linked to a minor groove binding element, and the resultant conjugate (9) was shown to bind and cleave DNA with sequence selectivity.
| Item Type: | Article | |||||||||
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| Additional Information: | © 1996 American Chemical Society. Received November 21, 1995. Publication Date (Web): May 28, 1996. Generous support from the National Institutes of Health is gratefully acknowledged. C.A.P. acknowledges support from NIH Training Grant T32GM08501. We also thank Professor Peter B. Dervan and his research group, with special thanks to Dr. Milan Mrksich, for their many helpful suggestions throughout the course of this work. | |||||||||
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| Record Number: | CaltechAUTHORS:20170919-134911678 | |||||||||
| Persistent URL: | http://resolver.caltech.edu/CaltechAUTHORS:20170919-134911678 | |||||||||
| Official Citation: | DNA Cleavage by an α,3-Dehydrotoluene Precursor Conjugated to a Minor Groove Binding Element. Andrew G. Myers and Cynthia A. Parrish. Bioconjugate Chemistry 1996 7 (3), 322-331. DOI: 10.1021/bc9600170 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 81573 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Tony Diaz | |||||||||
| Deposited On: | 19 Sep 2017 20:56 | |||||||||
| Last Modified: | 19 Sep 2017 20:56 |
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