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2'-Deoxy-3-isoadenosine Forms Hoogsteen-Type Base Pairs with Thymidine in the d(CG[iA]TCG)_2 Duplex^1

Bhat, Balkrishen and Leonard, Nelson J. and Robinson, Howard and Wang, Andrew H.-J. (1996) 2'-Deoxy-3-isoadenosine Forms Hoogsteen-Type Base Pairs with Thymidine in the d(CG[iA]TCG)_2 Duplex^1. Journal of the American Chemical Society, 118 (12). pp. 3065-3066. ISSN 0002-7863. doi:10.1021/ja954178a.

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Present-day genetic material, DNA and RNA, consists of five major nucleic acid bases (A, G, T, C, and U) and the sugar-phosphate backbone. In addition to the question of their selection from prebiotic matter, there are more subtle issues, including, in the case of purines, the site of attachment of ribose/deoxyribose at N9 versus N3. The reaction of adenine with protected sugar halides gives a mixture containing more or less equal amounts of N9 and N3 derivatives.

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Additional Information:© 1996 American Chemical Society. Received December 12, 1995. Publication Date (Web): March 27, 1996. This work was supported by the NIH grant GM-41612 to A.H.-J.W. The Varian VXR500 NMR spectrometer was supported in part from the NIH shared instrumentation grant 1S10RR06243.
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Issue or Number:12
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Official Citation:2‘-Deoxy-3-isoadenosine Forms Hoogsteen-Type Base Pairs with Thymidine in the d(CG[iA]TCG)2 Duplex. Balkrishen Bhat, Nelson J. Leonard, Howard Robinson, and Andrew H.-J. Wang, Journal of the American Chemical Society 1996 118 (12), 3065-3066. DOI: 10.1021/ja954178a
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:81613
Deposited By: Tony Diaz
Deposited On:20 Sep 2017 19:03
Last Modified:15 Nov 2021 19:44

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