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Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids

Gao, Wei and Nyein, Hnin Y. Y. and Shahpar, Ziba and Fahad, Hossain M. and Chen, Kevin and Emaminejad, Sam and Gao, Yuji and Tai, Li-Chia and Ota, Hiroki and Wu, Eric and Bullock, James and Zeng, Yuping and Lien, Der-Hsien and Javey, Ali (2016) Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids. ACS Sensors, 1 (7). pp. 866-874. ISSN 2379-3694.

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A flexible and wearable microsensor array is described for simultaneous multiplexed monitoring of heavy metals in human body fluids. Zn, Cd, Pb, Cu, and Hg ions are chosen as target analytes for detection via electrochemical square wave anodic stripping voltammetry (SWASV) on Au and Bi microelectrodes. The oxidation peaks of these metals are calibrated and compensated by incorporating a skin temperature sensor. High selectivity, repeatability, and flexibility of the sensor arrays are presented. Human sweat and urine samples are collected for heavy metal analysis, and measured results from the microsensors are validated through inductively coupled plasma mass spectrometry (ICP-MS). Real-time on-body evaluation of heavy metal (e.g., zinc and copper) levels in sweat of human subjects by cycling is performed to examine the change in concentrations with time. This platform is anticipated to provide insightful information about an individual’s health state such as heavy metal exposure and aid the related clinical investigations.

Item Type:Article
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URLURL TypeDescription Information
Gao, Wei0000-0002-8503-4562
Chen, Kevin0000-0002-6726-6132
Javey, Ali0000-0001-7214-7931
Additional Information:© 2016 American Chemical Society. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes. Received 26 April 2016. Date accepted 9 May 2016. Published online 9 May 2016. Published in print 22 July 2016. This work was supported by NSF Nanomanufacturing Systems for Mobile Computing and Energy Technologies (NASCENT) Center. The sensor fabrication was performed in the Electronic Materials (E-MAT) laboratory funded by the Director, Office of Science, Office of Basic Energy Sciences, Material Sciences and Engineering Division of the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. K.C. acknowledges support from the Robert N. Noyce Fellowship in Microelectronics. H.O. acknowledges support from the Japan Society for the Promotion of Science (JSPS) Fellowship.
Funding AgencyGrant Number
Department of Energy (DOE)DE-AC02-05CH11231
Robert N. Noyce FellowshipUNSPECIFIED
Japan Society for the Promotion of Science (JSPS)UNSPECIFIED
Subject Keywords:flexible electronics; heavy metals monitoring; multiplexed sensing; sweat; temperature compensation; wearable biosensors
Issue or Number:7
Record Number:CaltechAUTHORS:20170922-120826330
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Official Citation:Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids Wei Gao, Hnin Y. Y. Nyein, Ziba Shahpar, Hossain M. Fahad, Kevin Chen, Sam Emaminejad, Yuji Gao, Li-Chia Tai, Hiroki Ota, Eric Wu, James Bullock, Yuping Zeng, Der-Hsien Lien, and Ali Javey ACS Sensors 2016 1 (7), 866-874 DOI: 10.1021/acssensors.6b00287
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:81745
Deposited By: Ruth Sustaita
Deposited On:22 Sep 2017 20:48
Last Modified:09 Mar 2020 13:18

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