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Population regulation in microbial consortia using dual feedback control

Ren, Xinying and Baetica, Ania-Ariadna and Swaminathan, Anandh and Murray, Richard M. (2017) Population regulation in microbial consortia using dual feedback control. In: 2017 IEEE 56th Annual Conference on Decision and Control (CDC). IEEE , Piscataway, NJ, pp. 5341-5347. ISBN 978-1-5090-2874-0.

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An ongoing area of study in synthetic biology has been the design and construction of synthetic circuits that maintain homeostasis at the population level. Here, we are interested in designing a synthetic control circuit that regulates the total cell population and the relative ratio between cell strains in a culture containing two different cell strains. We have developed a dual feedback control strategy that uses two separate control loops to achieve the two functions respectively. By combining both of these control loops, we have created a population regulation circuit where both the total population size and relative cell type ratio can be set by reference signals. The dynamics of the regulation circuit show robustness and adaptation to perturbations in cell growth rate and changes in cell numbers. The control architecture is general and could apply to any organism for which synthetic biology tools for quorum sensing, comparison between outputs, and growth control are available.

Item Type:Book Section
Related URLs:
URLURL TypeDescription Paper Paper
Baetica, Ania-Ariadna0000-0003-0421-8181
Swaminathan, Anandh0000-0001-9935-6530
Murray, Richard M.0000-0002-5785-7481
Additional Information:The copyright holder for this preprint is the author/funder. bioRxiv preprint first posted online Mar. 24, 2017. The authors would like to thank Reed McCardell and Victoria Hsiao for their insightful discussion. The authors X. R., A. B., and A. S. are partially supported by the Air Force Office of Scientific Research, grant number FA9550-14-1-0060. The project depicted is also sponsored by the Defense Advanced Research Projects Agency (Agreement HR0011-17-2-0008). The content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred.
Funding AgencyGrant Number
Air Force Office of Scientific Research (AFOSR)FA9550-14-1-0060
Defense Advanced Research Projects Agency (DARPA)HR0011-17-2-0008
Record Number:CaltechAUTHORS:20170925-083417843
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Official Citation:X. Ren, A. A. Baetica, A. Swaminathan and R. M. Murray, "Population regulation in microbial consortia using dual feedback control," 2017 IEEE 56th Annual Conference on Decision and Control (CDC), Melbourne, Australia, 2017, pp. 5341-5347. doi: 10.1109/CDC.2017.8264450
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:81795
Deposited By: Tony Diaz
Deposited On:25 Sep 2017 17:36
Last Modified:09 Mar 2020 13:19

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