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Nicotine in the Endoplasmic Reticulum

Shivange, Amol V. and Nichols, Aaron L. and Borden, Philip M. and Kamjaya, Aron and Muthusamy, Anand K. and Jeon, Janice H. and Unger, Elizabeth K. and Tian, Lin and Marvin, Jonathan S. and Looger, Loren L. and Lester, Henry A. (2017) Nicotine in the Endoplasmic Reticulum. Journal of General Physiology, 149 (9). Art. No. 32. ISSN 0022-1295. https://resolver.caltech.edu/CaltechAUTHORS:20170929-092012776

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Abstract

Nicotine activates plasma membrane (PM) nicotinic receptors (nAChRs), but also permeates into the endoplasmic reticulum (ER) and cis-Golgi, and there binds to nascent nAChRs. Other psychiatric and abused drugs may also enter the ER and bind their classical targets. Further progress requires direct proof, quantification, and time resolution of these processes in live cells and in the brain of animals. Therefore, we are developing genetically encoded fluorescent biosensors to study the subcellular pharmacokinetics of neural drugs.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://jgp.rupress.org/content/149/9/889PublisherArticle
ORCID:
AuthorORCID
Lester, Henry A.0000-0002-5470-5255
Additional Information:© 2017 The Rockefeller University Press. After the Initial Publication Period, RUP will grant to the public the non-exclusive right to copy, distribute, or display the Article under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode, or updates thereof. Published September 4, 2017. Support: NIH, NARSAD, California TRDRP, and HHMI.
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
NARSADUNSPECIFIED
California Tobacco-Related Disease Research ProgramUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:9
Record Number:CaltechAUTHORS:20170929-092012776
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170929-092012776
Official Citation:ABSTRACTS OF PAPERS AT THE SEVENTY-FIRST ANNUAL MEETING OF THE SOCIETY OF GENERAL PHYSIOLOGISTS: The Optical Revolution in Physiology: From Membrane to Brain The Journal of General Physiology Sep 2017, 149(9) 889.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:81917
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:29 Sep 2017 16:36
Last Modified:03 Oct 2019 18:48

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