Shivange, Amol V. and Nichols, Aaron L. and Borden, Philip M. and Kamjaya, Aron and Muthusamy, Anand K. and Jeon, Janice H. and Unger, Elizabeth K. and Tian, Lin and Marvin, Jonathan S. and Looger, Loren L. and Lester, Henry A. (2017) Nicotine in the Endoplasmic Reticulum. Journal of General Physiology, 149 (9). Art. No. 32. ISSN 0022-1295. doi:10.1085/jgp.149.9.889. https://resolver.caltech.edu/CaltechAUTHORS:20170929-092012776
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Abstract
Nicotine activates plasma membrane (PM) nicotinic receptors (nAChRs), but also permeates into the endoplasmic reticulum (ER) and cis-Golgi, and there binds to nascent nAChRs. Other psychiatric and abused drugs may also enter the ER and bind their classical targets. Further progress requires direct proof, quantification, and time resolution of these processes in live cells and in the brain of animals. Therefore, we are developing genetically encoded fluorescent biosensors to study the subcellular pharmacokinetics of neural drugs.
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| Additional Information: | © 2017 The Rockefeller University Press. After the Initial Publication Period, RUP will grant to the public the non-exclusive right to copy, distribute, or display the Article under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode, or updates thereof. Published September 4, 2017. Support: NIH, NARSAD, California TRDRP, and HHMI. | ||||||||||||||
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| Issue or Number: | 9 | ||||||||||||||
| DOI: | 10.1085/jgp.149.9.889 | ||||||||||||||
| Record Number: | CaltechAUTHORS:20170929-092012776 | ||||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20170929-092012776 | ||||||||||||||
| Official Citation: | ABSTRACTS OF PAPERS AT THE SEVENTY-FIRST ANNUAL MEETING OF THE SOCIETY OF GENERAL PHYSIOLOGISTS: The Optical Revolution in Physiology: From Membrane to Brain The Journal of General Physiology Sep 2017, 149(9) 889. | ||||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||
| ID Code: | 81917 | ||||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||||
| Deposited By: | Tony Diaz | ||||||||||||||
| Deposited On: | 29 Sep 2017 16:36 | ||||||||||||||
| Last Modified: | 15 Nov 2021 19:47 |
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