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SutA is a Global Transcriptional Regulator Operating during Slow Growth in Pseudomonas Aeruginosa

Bergkessel, M. and Newman, D. K. and Babin, B. and Tirrell, D. A. (2017) SutA is a Global Transcriptional Regulator Operating during Slow Growth in Pseudomonas Aeruginosa. Pediatric Pulmonology, 52 (S47). S366-S367. ISSN 8755-6863. https://resolver.caltech.edu/CaltechAUTHORS:20171012-102706675

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Abstract

Chronic Pseudomonas aeruginosa infections, a major cause of morbidity and mortality for CF patients, are highly resistant to antibiotic treatment, and many lines of evidence suggest that this is due in part to slow-growing states imposed by the lung environment. In previously published work (Babin BM, et al. Proc Natl Acad Sci 2016;113(5):E597-605), we identified a novel RNA polymerase-binding protein that is post-transcriptionally upregulated under such slow-growth conditions. We named this small, acidic protein SutA, and showed using RNA-Seq and ChIP-Seq that it associates with RNA polymerase (RNAP) at many genomic regions, and tends to positively affect transcript levels for genes with which it associates. The genes that are affected include ribosomal RNA and protein genes, and other genes with roles in metabolism and stress survival. Furthermore, we showed that deletion of the sutA gene confers a disadvantage on cells subjected to fluctuations between growth-arrested and growth-promoting states. Thus, SutA may contribute to survival of Pseudomonas aeruginosa in environments like the CF lung, where oxygen and nutrient availability are likely to be heterogeneous in time and space.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/ppul.23840DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/ppul.23840/fullPublisherArticle
ORCID:
AuthorORCID
Bergkessel, M.0000-0002-4530-1224
Newman, D. K.0000-0003-1647-1918
Babin, B.0000-0002-4133-6665
Tirrell, D. A.0000-0003-3175-4596
Additional Information:© 2017 Wiley Periodicals, Inc. Issue online: 19 September 2017; Version of record online: 19 September 2017.
Issue or Number:S47
Record Number:CaltechAUTHORS:20171012-102706675
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20171012-102706675
Official Citation:(2017), Poster Session Abstracts. Pediatr Pulmonol., 52: S214–S516. doi:10.1002/ppul.23840
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:82307
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Oct 2017 22:22
Last Modified:09 Mar 2020 13:18

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