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Association Among Gut Microbes, Intestinal Physiology, and Autism

Wu, Wei-Li (2017) Association Among Gut Microbes, Intestinal Physiology, and Autism. EBioMedicine, 25 . pp. 11-12. ISSN 2352-3964. PMCID PMC5704070. https://resolver.caltech.edu/CaltechAUTHORS:20171018-105425692

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Abstract

Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders characterized by two core symptoms: social deficits and increase in stereotypic/repetitive behaviors. Along with the core symptoms of ASD, other comorbid conditions can be observed in certain populations of people with ASD, such as gastrointestinal (GI) complications and altered gut microbiome (Adams et al., 2011 ; Parracho et al., 2005). Homeostasis of the GI system is closely regulated by the gut microbiota. Therefore, whether the gut microbiota is a contributing factor for ASD has been postulated recently. Several key questions have been raised. Do gut microbes contribute to the behavioral symptoms in ASD? How do gut microbes affect behavioral output through the gut–brain axis? How do gut and brain communicate with each other? Due to the complexity of the distal connection between gut and brain, these are the key questions that remain unanswered in the field.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.ebiom.2017.10.013DOIArticle
http://www.sciencedirect.com/science/article/pii/S2352396417304000PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704070PubMed CentralArticle
Additional Information:© 2017 The Author. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Received 3 October 2017, Revised 6 October 2017, Accepted 6 October 2017, Available online 13 October 2017. The author declares no conflicts of interest.
Subject Keywords:Gut microbiota; Intestinal physiology; Serotonin (5-HT); Bile acid; BTBR; Autism
PubMed Central ID:PMC5704070
Record Number:CaltechAUTHORS:20171018-105425692
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20171018-105425692
Official Citation:Wei-Li Wu, Association Among Gut Microbes, Intestinal Physiology, and Autism, In EBioMedicine, Volume 25, 2017, Pages 11-12, ISSN 2352-3964, https://doi.org/10.1016/j.ebiom.2017.10.013. (http://www.sciencedirect.com/science/article/pii/S2352396417304000)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:82453
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:18 Oct 2017 23:02
Last Modified:03 Oct 2019 18:54

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