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Directed Evolution: Bringing New Chemistry to Life

Arnold, Frances H. (2018) Directed Evolution: Bringing New Chemistry to Life. Angewandte Chemie International Edition, 57 (16). pp. 4143-4148. ISSN 1433-7851. PMCID PMC5901037. http://resolver.caltech.edu/CaltechAUTHORS:20171024-105338006

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Abstract

Tailor-made: Discussed herein is the ability to adapt biology's mechanisms for innovation and optimization to solving problems in chemistry and engineering. The evolution of nature's enzymes can lead to the discovery of new reactivity, transformations not known in biology, and reactivity inaccessible by small-molecule catalysts.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/anie.201708408DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/anie.201708408/abstractPublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901037PubMed CentralArticle
ORCID:
AuthorORCID
Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited, and is not used for commercial purposes. Version of record online: 28 November 2017; Accepted manuscript online: 24 October 2017; Manuscript Received: 15 August 2017. I thank Sabine Brinkmann-Chen, Kai Chen, Stephan Hammer, Kari Hernandez, Xiongyi Huang, Jennifer Kan, Rusty Lewis, Chris Prier and Ruijie Zhang for the ideas, inspiration, data, and hard work that went into the examples presented here. I thank Kim Mayer for excellent editorial assistance. This work was supported by the National Science Foundation, Division of Molecular and Cellular Biosciences (grant MCB-1513007), the Resnick Sustainability Institute, and the Caltech CI2 innovation program. The author declares no conflict of interest.
Group:Resnick Sustainability Institute
Funders:
Funding AgencyGrant Number
NSFMCB-1513007
Resnick Sustainability InstituteUNSPECIFIED
Caltech Innovation Initiative (CI2)UNSPECIFIED
Subject Keywords:biocatalysis; enzymes; heme proteins; protein engineering; synthetic methods
PubMed Central ID:PMC5901037
Record Number:CaltechAUTHORS:20171024-105338006
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20171024-105338006
Official Citation:F. H. Arnold, Angew. Chem. Int. Ed. 2018, 57, 4143.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:82615
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Oct 2017 18:02
Last Modified:01 Nov 2018 21:00

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