Diskin, Ron and Bjorkman, Pamela J. and Nussenzweig, Michel and Scheid, Johannes (2016) Antibodies directed toward the HIV-1 GP120 CD4 binding site with increased potency and breadth. Patent number: US9493549B2. https://resolver.caltech.edu/CaltechAUTHORS:20171025-161147200
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Abstract
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) potent VRC01-like (PVL) antibodies targeted to gp120 having an amino acid substitution in the heavy chain at a residue in the anti-CD4 binding site PVL antibody that is equivalent to Phe43 in CD4 and an amino acid substitution in the light chain, these antibodies having improved potency and breadth.
| Item Type: | Patent | |||||||||
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| Related Patents: | US20130209454A1 | |||||||||
| Patent Classification: | Current U.S. Class: 1/1. Current CPC Class: C07K 16/1063 (20130101); C07K 16/10 (20130101); C07K 2317/21 (20130101); C07K 2317/34 (20130101); C07K 2317/76 (20130101); C07K 2317/92 (20130101); C07K 2317/565 (20130101). Current International Class: C07K 16/10 (20060101). | |||||||||
| Patent Assignee: | California Institute of Technology, Rockefeller University | |||||||||
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| Alternate Title: | Anti-hiv antibodies having increased potency and breadth | |||||||||
| Additional Information: | Application title: Anti-hiv antibodies having increased potency and breadth. US Grant. Application number US13714398. Priority date 2011-07-25. Filing date 2012-12-13. Publication date 2016-11-15. Grant date 2016-11-15. Government Interests: This invention was made with government support under P01 A1081677-01, awarded by the National Institutes of Health. The government has certain rights in the invention. Parent Case Text: The present application claims priority to and the benefit of U.S. Provisional Application Ser. No. 61/570,173 filed on Dec. 13, 2011, and is continuation in part of U.S. patent application Ser. No. 13/558,312, filed Jul. 25, 2012, the entire contents of both of which are incorporated herein by reference. | |||||||||
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| Record Number: | CaltechAUTHORS:20171025-161147200 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20171025-161147200 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 82687 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Katherine Johnson | |||||||||
| Deposited On: | 25 Oct 2017 23:22 | |||||||||
| Last Modified: | 03 Oct 2019 18:57 |
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