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Antibodies directed toward the HIV-1 GP120 CD4 binding site with increased potency and breadth

Diskin, Ron and Bjorkman, Pamela J. and Nussenzweig, Michel and Scheid, Johannes (2016) Antibodies directed toward the HIV-1 GP120 CD4 binding site with increased potency and breadth. Patent number: US9493549B2.

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Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) potent VRC01-like (PVL) antibodies targeted to gp120 having an amino acid substitution in the heavy chain at a residue in the anti-CD4 binding site PVL antibody that is equivalent to Phe43 in CD4 and an amino acid substitution in the light chain, these antibodies having improved potency and breadth.

Item Type:Patent
Related Patents:US20130209454A1
Patent Classification:Current U.S. Class: 1/1. Current CPC Class: C07K 16/1063 (20130101); C07K 16/10 (20130101); C07K 2317/21 (20130101); C07K 2317/34 (20130101); C07K 2317/76 (20130101); C07K 2317/92 (20130101); C07K 2317/565 (20130101). Current International Class: C07K 16/10 (20060101).
Patent Assignee:California Institute of Technology, Rockefeller University
Related URLs:
URLURL TypeDescription Patents site Patent Office
Diskin, Ron0000-0002-2837-5897
Bjorkman, Pamela J.0000-0002-2277-3990
Nussenzweig, Michel0000-0003-0592-8564
Alternate Title:Anti-hiv antibodies having increased potency and breadth
Additional Information:Application title: Anti-hiv antibodies having increased potency and breadth. US Grant. Application number US13714398. Priority date 2011-07-25. Filing date 2012-12-13. Publication date 2016-11-15. Grant date 2016-11-15. Government Interests: This invention was made with government support under P01 A1081677-01, awarded by the National Institutes of Health. The government has certain rights in the invention. Parent Case Text: The present application claims priority to and the benefit of U.S. Provisional Application Ser. No. 61/570,173 filed on Dec. 13, 2011, and is continuation in part of U.S. patent application Ser. No. 13/558,312, filed Jul. 25, 2012, the entire contents of both of which are incorporated herein by reference.
Funding AgencyGrant Number
NIHP01 A1081677-01
Record Number:CaltechAUTHORS:20171025-161147200
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:82687
Deposited By: Katherine Johnson
Deposited On:25 Oct 2017 23:22
Last Modified:03 Oct 2019 18:57

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