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On demonstrating DNA intercalation

Long, Eric C. and Barton, Jacqueline K. (1990) On demonstrating DNA intercalation. Accounts of Chemical Research, 23 (9). pp. 271-273. ISSN 0001-4842. https://resolver.caltech.edu/CaltechAUTHORS:20171108-084900678

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Abstract

Considerable attention has focused on new DNA-binding and -modifying agents, from natural products to wholly synthetic designs, as probes of DNA structure and as potential chemotherapeutic agents. The application of these molecules necessitates a precise understanding of the structural details of the agents' mode of interaction with the target molecule, double-helical DNA. DNA binding agents tend to interact noncovalently with the host molecule through two general modes: (i) in a groove-bound fashion stabilized by a mixture of hydrophobic, electrostatic, and hydrogen-bonding interactions and (ii) through an intercalative association in which a planar, heteroaromatic moiety slides between the DNA base pairs. Surprisingly, however, only a fraction of known DNA-interactive agents have been structurally characterized to atomic detail in noncovalent complexes with DNA.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/ar00177a001DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ar00177a001PublisherArticle
ORCID:
AuthorORCID
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 1990 by the American Chemical Society. Registered in U.S. Patent and Trademark Office. We are grateful to the National Institutes of Health for their support of our work. E.C.L. is a Fellow of the Jane Coffin Childs Memorial Fund for Medical Research.
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
Jane Coffin Childs Memorial Fund for Medical ResearchUNSPECIFIED
Issue or Number:9
Record Number:CaltechAUTHORS:20171108-084900678
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20171108-084900678
Official Citation:On demonstrating DNA intercalation. Eric C. Long and Jacqueline K. Barton. Accounts of Chemical Research 1990 23 (9), 271-273. DOI: 10.1021/ar00177a001
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:83056
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:08 Nov 2017 18:22
Last Modified:03 Oct 2019 19:01

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