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Vectored gene delivery for lifetime animal contraception: Overview and hurdles to implementation

Hay, Bruce A. and Li, Juan and Guo, Ming (2018) Vectored gene delivery for lifetime animal contraception: Overview and hurdles to implementation. Theriogenology, 112 . pp. 63-74. ISSN 0093-691X. doi:10.1016/j.theriogenology.2017.11.003. https://resolver.caltech.edu/CaltechAUTHORS:20171108-092343114

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Abstract

There is a need for permanent, non-surgical methods of contraception for many animal species. Here we discuss the hypothesis that transgene-mediated expression of fertility inhibiting molecules such as monoclonal antibodies, ligands for cell surface receptors, receptor decoys, or small RNAs can provide such a method, which we term vectored contraception. We outline the technologies involved, progress made, and discuss challenges to implementation.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.theriogenology.2017.11.003DOIArticle
http://www.sciencedirect.com/science/article/pii/S0093691X17305381PublisherArticle
Additional Information:© 2017 Published by Elsevier Inc. Received 26 March 2017, Revised 25 October 2017, Accepted 2 November 2017, Available online 8 November 2017. This work was supported by funds to BAH from the California Institute of Technology.
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Funding AgencyGrant Number
CaltechUNSPECIFIED
Subject Keywords:Contraception; GnRH; Zona pellucida; Anti-mullerian hormone; Adeno-associated virus
DOI:10.1016/j.theriogenology.2017.11.003
Record Number:CaltechAUTHORS:20171108-092343114
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20171108-092343114
Official Citation:Vectored gene delivery for lifetime animal contraception: Overview and hurdles to implementation Hay, Bruce A. et al. Theriogenology , Volume 112 , 63 - 74
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:83060
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:08 Nov 2017 18:15
Last Modified:15 Nov 2021 19:55

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