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In vivo study of optical speckle decorrelation time across depths in the mouse brain

Qureshi, Muhammad Mohsin and Brake, Joshua and Jeon, Hee-Jae and Ruan, Haowen and Liu, Yan and Safi, Abdul Mohaimen and Eom, Tae Joong and Yang, Changhuei and Chung, Euiheon (2017) In vivo study of optical speckle decorrelation time across depths in the mouse brain. Biomedical Optics Express, 8 (11). pp. 4855-4864. ISSN 2156-7085. PMCID PMC5695936; PMC5695950.

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The strong optical scattering of biological tissue confounds our ability to focus light deeply into the brain beyond depths of a few hundred microns. This challenge can be potentially overcome by exploiting wavefront shaping techniques which allow light to be focused through or inside scattering media. However, these techniques require the scattering medium to be static, as changes in the arrangement of the scatterers between the wavefront recording and playback steps reduce the fidelity of the focus that is formed. Furthermore, as the thickness of the scattering medium increases, the influence of the dynamic nature becomes more severe due to the growing number of scattering events experienced by each photon. In this paper, by examining the scattering dynamics in the mouse brain in vivo via multispeckle diffusing wave spectroscopy (MSDWS) using a custom fiber probe that simulates a point-like source within the brain, we investigate the relationship between this decorrelation time and the depth of the point-like light source inside the living mouse brain at depths up to 3.2 mm.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle CentralErratum
Qureshi, Muhammad Mohsin0000-0003-0362-0144
Brake, Joshua0000-0002-5113-6886
Ruan, Haowen0000-0002-4917-4509
Liu, Yan0000-0002-5837-4908
Safi, Abdul Mohaimen0000-0003-1117-0286
Eom, Tae Joong0000-0003-0556-4027
Yang, Changhuei0000-0001-8791-0354
Chung, Euiheon0000-0002-3326-6927
Additional Information:© 2017 Optical Society of America. Received 16 Aug 2017; revised 10 Sep 2017; accepted 25 Sep 2017; published 4 Oct 2017. Disclosures: The authors declare that there are no conflicts of interest related to this article. This work was supported in part by GIST Research Institute (GRI), and the GIST-Caltech Research Collaboration Project through a grant provided by GIST in 2017, a research grant (NRF-2016R1A2B4015381), the Brain Research Program (NRF-2017M3C7A 1044964) of the National Research Foundation (NRF), the KBRI basic research program through Korea Brain Research Institute (17-BR-04) funded by the Ministry of Science, ICT, Future Planning, the industrial convergence foundation construction program (N0002310) funded by the Ministry of Trade, Industry & Energy, and the National Institutes of Health (NIH) (U01NS090577). J.B. was supported by the National Institute of Biomedical Imaging, and Bioengineering (F31EB021153) under a Ruth L. Kirschstein National Research Service Award and by the Donna and Benjamin M. Rosen Bioengineering Center. The authors thank Ms. Ji Hye Yang from GIST for her help during the animal experiment.
Errata:The last sentence of the 2nd paragraph of section “4. Results” should read: “The respective mean decorrelation times for 1.1, 1.8, 2.5, and 3.2 mm depth of point-like source are 5.3, 1.5, 0.37, and 0.26 ms, with standard deviations of 4.8, 1.6, 0.16, 0.13 ms.” instead of the version in the manuscript (copied below) which contains incorrect values. “The respective mean decorrelation times for 1.1, 1.8, 2.5, and 3.2 mm depth of point-like source are 7.5, 3.5, 1.1, and 0.6 ms, with standard deviations of 5.9, 2.4, 0.6, and 0.3 ms.”
Group:Rosen Bioengineering Center
Funding AgencyGrant Number
GIST Research Institute (GRI)UNSPECIFIED
GIST-Caltech Research Collaboration ProjectUNSPECIFIED
National Research Foundation of KoreaNRF-2016R1A2B4015381
National Research Foundation of KoreaNRF-2017M3C7A 1044964
Ministry of Science, ICT, Future Planning (Korea)17-BR-04
Ministry of Trade, Industry and Energy (Korea)N0002310
Donna and Benjamin M. Rosen Bioengineering CenterUNSPECIFIED
Issue or Number:11
Classification Code:OCIS codes: (030.6140) Speckle; (170.3660) Light propagation in tissues; (170.7050) Turbid media
PubMed Central ID:PMC5695936; PMC5695950
Record Number:CaltechAUTHORS:20171117-083356029
Persistent URL:
Official Citation:Muhammad Mohsin Qureshi, Joshua Brake, Hee-Jae Jeon, Haowen Ruan, Yan Liu, Abdul Mohaimen Safi, Tae Joong Eom, Changhuei Yang, and Euiheon Chung, "In vivo study of optical speckle decorrelation time across depths in the mouse brain: erratum," Biomed. Opt. Express 8, 5039-5039 (2017)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:83283
Deposited By: Tony Diaz
Deposited On:20 Nov 2017 19:33
Last Modified:20 Nov 2020 22:07

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