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High-speed single-shot optical focusing through dynamic scattering media with full-phase wavefront shaping

Hemphill, Ashton S. and Shen, Yuecheng and Liu, Yan and Wang, Lihong V. (2017) High-speed single-shot optical focusing through dynamic scattering media with full-phase wavefront shaping. Applied Physics Letters, 111 (22). Art. No. 221109. ISSN 0003-6951. PMCID PMC5709093. doi:10.1063/1.5009113.

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In biological applications, optical focusing is limited by the diffusion of light, which prevents focusing at depths greater than ∼1 mm in soft tissue. Wavefront shaping extends the depth by compensating for phase distortions induced by scattering and thus allows for focusing light through biological tissue beyond the optical diffusion limit by using constructive interference. However, due to physiological motion, light scattering in tissue is deterministic only within a brief speckle correlation time. In in vivo tissue, this speckle correlation time is on the order of milliseconds, and so the wavefront must be optimized within this brief period. The speed of digital wavefront shaping has typically been limited by the relatively long time required to measure and display the optimal phase pattern. This limitation stems from the low speeds of cameras, data transfer and processing, and spatial light modulators. While binary-phase modulation requiring only two images for the phase measurement has recently been reported, most techniques require at least three frames for the full-phase measurement. Here, we present a full-phase digital optical phase conjugation method based on off-axis holography for single-shot optical focusing through scattering media. By using off-axis holography in conjunction with graphics processing unit based processing, we take advantage of the single-shot full-phase measurement while using parallel computation to quickly reconstruct the phase map. With this system, we can focus light through scattering media with a system latency of approximately 9 ms, on the order of the in vivo speckle correlation time.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Shen, Yuecheng0000-0003-1990-8142
Liu, Yan0000-0002-5837-4908
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2017 Published by AIP Publishing. Received 12 October 2017; accepted 3 November 2017; published online 30 November 2017. We thank Jim Ballard for help in the revision and editing of the manuscript. This work was sponsored by NIH Grants No. DP1 EB016986 (NIH Director's Pioneer Award) and R01 CA186567 (NIH Director's Transformative Research Award).
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 CA186567
Subject Keywords:Molecular dynamics; Holography; Optical modulators; Computer hardware; Wave mechanics
Issue or Number:22
PubMed Central ID:PMC5709093
Record Number:CaltechAUTHORS:20171130-090421392
Persistent URL:
Official Citation:High-speed single-shot optical focusing through dynamic scattering media with full-phase wavefront shaping. Ashton S. Hemphill, Yuecheng Shen, Yan Liu, and Lihong V. Wang. Applied Physics Letters 2017 111:22
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:83588
Deposited By: Tony Diaz
Deposited On:30 Nov 2017 17:34
Last Modified:21 Mar 2022 16:36

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