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Non ictal onset zone: A window to ictal dynamics

Afra, Pegah and Hanrahan, Sara J. and Kellis, Spencer Sterling and House, Paul (2017) Non ictal onset zone: A window to ictal dynamics. Epilepsy & Behavior Case Reports, 8 . pp. 123-127. ISSN 2213-3232. PMCID PMC5707213.

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The focal and network concepts of epilepsy present different aspects of electroclinical phenomenon of seizures. Here, we present a 23-year-old man undergoing surgical evaluation with left fronto-temporal electrocorticography (ECoG) and microelectrode-array (MEA) in the middle temporal gyrus (MTG). We compare action-potential (AP) and local field potentials (LFP) recorded from MEA with ECoG. Seizure onset in the mesial-temporal lobe was characterized by changes in the pattern of AP-firing without clear changes in LFP or ECoG in MTG. This suggests simultaneous analysis of neuronal activity in differing spatial scales and frequency ranges provide complementary insights into how focal and network neurophysiological activity contribute to ictal activity.

Item Type:Article
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URLURL TypeDescription CentralArticle
Kellis, Spencer Sterling0000-0002-5158-1058
Additional Information:© 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( Received 23 May 2017, Revised 3 October 2017, Accepted 11 October 2017, Available online 21 October 2017. This work was supported by a Utah Research Foundation grant to BG. J. Egan for the action potential sorting. The authors wish to thank Dr. Bradley Greger for his helpful comments and review of this manuscript, Ms. Kristin Kraus for her editorial assistance, the EEG staff for their assistance in conducting this study, and most importantly the patient who participated selflessly in this research.
Funding AgencyGrant Number
Utah Research FoundationUNSPECIFIED
Subject Keywords:Microelectrode array; Ictal dynamics; Microgrid; Single neuron recording; Ictal onset
PubMed Central ID:PMC5707213
Record Number:CaltechAUTHORS:20171211-083543350
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Official Citation:Pegah Afra, Sara J. Hanrahan, Spencer Sterling Kellis, Paul House, Non ictal onset zone: A window to ictal dynamics, In Epilepsy & Behavior Case Reports, Volume 8, 2017, Pages 123-127, ISSN 2213-3232, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:83786
Deposited By: Tony Diaz
Deposited On:12 Dec 2017 22:37
Last Modified:09 Mar 2020 13:18

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