Ruan, Haowen and Haber, Tom and Liu, Yan and Brake, Joshua and Kim, Jinho and Berlin, Jacob M. and Yang, Changhuei (2017) Focusing light inside scattering media with magnetic-particle-guided wavefront shaping. Optica, 4 (11). pp. 1337-1343. ISSN 2334-2536. PMCID PMC5881932. doi:10.1364/OPTICA.4.001337. https://resolver.caltech.edu/CaltechAUTHORS:20171211-091117607
![]() |
PDF
- Published Version
See Usage Policy. 1MB |
![]() |
PDF
- Accepted Version
See Usage Policy. 1MB |
![]() |
PDF
- Supplemental Material
See Usage Policy. 1MB |
![]() |
Video (AVI) (SuppVideo1_MagBeads25Hz)
- Supplemental Material
See Usage Policy. 974kB |
![]() |
Video (AVI) (SuppVideo2_MagBeads5Hz)
- Supplemental Material
See Usage Policy. 973kB |
![]() |
Video (AVI) (SuppVideo3_Cell25Hz)
- Supplemental Material
See Usage Policy. 550kB |
![]() |
Video (AVI) (SuppVideo4_Cell5Hz)
- Supplemental Material
See Usage Policy. 551kB |
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20171211-091117607
Abstract
Optical scattering has traditionally limited the ability to focus light inside scattering media such as biological tissue. Recently developed wavefront shaping techniques promise to overcome this limit by tailoring an optical wavefront to constructively interfere at a target location deep inside scattering media. To find such a wavefront solution, a “guidestar” mechanism is required to identify the target location. However, developing guidestars of practical usefulness is challenging, especially in biological tissue, which hinders the translation of wavefront shaping techniques. Here, we demonstrate a guidestar mechanism that relies on magnetic modulation of small particles. This guidestar method features an optical modulation efficiency of 29% and enables micrometer-scale focusing inside biological tissue with a peak intensity-to-background ratio (PBR) of 140; both numbers are one order of magnitude higher than those achieved with the ultrasound guidestar, a popular guidestar method. We also demonstrate that light can be focused on cells labeled with magnetic particles, and to different target locations by magnetically controlling the position of a particle. Since magnetic fields have a large penetration depth even through bone structures like the skull, this optical focusing method holds great promise for deep-tissue applications such as optogenetic modulation of neurons, targeted light-based therapy, and imaging.
Item Type: | Article | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Related URLs: |
| ||||||||||||||
ORCID: |
| ||||||||||||||
Additional Information: | © 2017 Optical Society of America. Received 21 August 2017; revised 27 September 2017; accepted 28 September 2017 (Doc. ID 305214); published 25 October 2017. Funding: National Institutes of Health (NIH) (F31EB021153, U01NS090577); GIST-Caltech Collaborative Research Proposal (CG2016); Donna and Benjamin M. Rosen Bioengineering Center; Israel-City of Hope Fellowship Program in Biomedical Research. The authors would like to thank Dr. Euiheon Chung, Dr. Mooseok Jang, Dr. Ethan White, Dr. Kathleen Elison, Dr. Mikhail Shapiro, Dr. George Lu, and Mr. Hunter Davis for assistance and helpful discussions. TEM imaging was conducted at the Electron Microscopy core at City of Hope with Marcia Millier, Zhuo Li and Ricardo Zerda. | ||||||||||||||
Group: | Rosen Bioengineering Center | ||||||||||||||
Funders: |
| ||||||||||||||
Issue or Number: | 11 | ||||||||||||||
Classification Code: | OCIS codes: (190.5040) Phase conjugation; (110.0113) Imaging through turbid media; (110.1080) Active or adaptive optics; (090.2880) Holographic interferometry | ||||||||||||||
PubMed Central ID: | PMC5881932 | ||||||||||||||
DOI: | 10.1364/OPTICA.4.001337 | ||||||||||||||
Record Number: | CaltechAUTHORS:20171211-091117607 | ||||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20171211-091117607 | ||||||||||||||
Official Citation: | Haowen Ruan, Tom Haber, Yan Liu, Joshua Brake, Jinho Kim, Jacob M. Berlin, and Changhuei Yang, "Focusing light inside scattering media with magnetic-particle-guided wavefront shaping," Optica 4, 1337-1343 (2017) | ||||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||
ID Code: | 83789 | ||||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||||
Deposited By: | Tony Diaz | ||||||||||||||
Deposited On: | 12 Dec 2017 22:36 | ||||||||||||||
Last Modified: | 21 Mar 2022 16:56 |
Repository Staff Only: item control page