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A microscale optical implant for continuous in vivo monitoring of intraocular pressure

Lee, Jeong Oen and Park, Haeri and Du, Juan and Balakrishna, Ashwin and Chen, Oliver and Sretavan, David and Choo, Hyuck (2017) A microscale optical implant for continuous in vivo monitoring of intraocular pressure. Microsystems and Nanoengineering, 3 . Art. No. 17057. ISSN 2055-7434.

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Intraocular pressure (IOP) is a key clinical parameter in glaucoma management. However, despite the potential utility of daily measurements of IOP in the context of disease management, the necessary tools are currently lacking, and IOP is typically measured only a few times a year. Here we report on a microscale implantable sensor that could provide convenient, accurate, on-demand IOP monitoring in the home environment. When excited by broadband near-infrared (NIR) light from a tungsten bulb, the sensor’s optical cavity reflects a pressure-dependent resonance signature that can be converted to IOP. NIR light is minimally absorbed by tissue and is not perceived visually. The sensor’s nanodot-enhanced cavity allows for a 3–5 cm readout distance with an average accuracy of 0.29 mm Hg over the range of 0–40 mm Hg. Sensors were mounted onto intraocular lenses or silicone haptics and secured inside the anterior chamber in New Zealand white rabbits. Implanted sensors provided continuous in vivo tracking of short-term transient IOP elevations and provided continuous measurements of IOP for up to 4.5 months.

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Choo, Hyuck0000-0002-8903-7939
Additional Information:© 2017 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit Received: 23 April 2017; Revised: 07 July 2017; Accepted: 08 July 2017; Published online: 18 December 2017. The project was funded by the National Institute of Health (NIH) EY024582, a Research to Prevent Blindness Stein Innovation Award to D.S., a Research to Prevent Blindness unrestricted grant to UCSF Department of Ophthalmology, HMRI Investigator Award to HC, Caltech CI2 program, Powell Foundation Award to HC, and Burroughs Wellcome Funds to HC. JOL was partially supported for a year by the Basic Science Research Program through the National Research Foundation of Korea (NRF) under the Ministry of Education (NRF-2013R1A6A3A03026384). Competing interests: The authors declare no conflict of interest.
Funding AgencyGrant Number
Research to Prevent BlindnessUNSPECIFIED
Hunter Medical Research Institute (HMRI)UNSPECIFIED
Caltech Innovation Initiative (CI2)UNSPECIFIED
Charles Lee Powell FoundationUNSPECIFIED
Burroughs Wellcome FundUNSPECIFIED
National Research Foundation of KoreaNRF-2013R1A6A3A03026384
Subject Keywords:glaucoma; intraocular pressure (IOP); microscale sensor implant; in vivo continuous monitoring; remote optical readout; near-infrared (NIR) broadband light; minimally invasive
Record Number:CaltechAUTHORS:20171219-103155010
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:83963
Deposited By: Tony Diaz
Deposited On:19 Dec 2017 19:10
Last Modified:03 Oct 2019 19:13

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