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Abstinent Heroin Addicts Tend to Take Risks: ERP and Source Localization

Zhao, Qinglin and Li, Hongqian and Hu, Bin and Wu, Haiyan and Liu, Quanying (2017) Abstinent Heroin Addicts Tend to Take Risks: ERP and Source Localization. Frontiers in Neuroscience, 11 . Art. No. 681. ISSN 1662-4548. https://resolver.caltech.edu/CaltechAUTHORS:20171220-133552491

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Abstract

Abnormal decision making is a behavioral characteristic of drug addiction. Indeed, drug addicts prefer immediate rewards at the expense of future interests. Assessing the neurocognitive basis of decision-making related to drug dependence, combining event-related potential (ERP) analysis and source localization techniques, may provide new insights into understanding decision-making deficits in drug addicts and further guide withdrawal treatment. In this study, EEG was performed in 20 abstinent heroin addicts (AHAs) and 20 age-, education- and gender-matched healthy controls (HCs) while they participated in a simple two-choice gambling task (99 vs. 9). Our behavioral results showed that AHAs tend to select higher-risk choices compared with HCs (i.e., more “99” choices than “9”). ERP results showed that right hemisphere preponderance of stimulus-preceding negativity was disrupted in AHAs, but not in HCs. Feedback-related negativity of difference wave was higher in AHAs than HCs, with the P300 amplitude associated with risk magnitude and valence. Using source localization that allows identification of abnormal brain activity in consequential cognitive stages, including the reward expectation and outcome evaluation stages, we found abnormalities in both behavioral and neural responses on gambling in AHAs. Taken together, our findings suggest AHAs have risk-prone tendency and dysfunction in adaptive decision making, since they continue to choose risky options even after accruing considerable negative scores, and fail to shift to a safer strategy to avoid risk. Such abnormal decision-making bias to risk and immediate reward seeking may be accompanied by abnormal reward expectation and evaluation in AHAs, which explains their high risk-seeking and impulsivity.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.3389/fnins.2017.00681DOIArticle
https://www.frontiersin.org/articles/10.3389/fnins.2017.00681/fullPublisherArticle
Additional Information:© 2017 Zhao, Li, Hu, Wu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Received: 12 September 2017; Accepted: 21 November 2017; Published: 06 December 2017. Author Contributions: Study conception and design: BH and QL. Acquisition of data: QZ and HL. Analysis and interpretation of data: HL, BH, HW, and QL. Manuscript writing: All authors. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. This work was supported by the National Basic Research Program of China (973 Program) (No. 2014CB744600), the Program of International S&T Cooperation of MOST (No. 2013DFA11140), the National Natural Science Foundation of China (grant No. 61210010, No. 61632014), the National key foundation for developing scientific instruments (No. 61627808), and Program of Beijing Municipal Science & Technology Commission (No. Z171100000117005). QL was supported by James Boswell Fellowship.
Funders:
Funding AgencyGrant Number
National Basic Research Program of China2014CB744600
Ministry of Science and Technology (China)2013DFA11140
National Natural Science Foundation of China61210010
National Natural Science Foundation of China61632014
National key foundation for developing scientific instruments61627808
Beijing Municipal Science & Technology CommissionZ171100000117005
James G. Boswell FoundationUNSPECIFIED
Subject Keywords:gambling task, decision making, ERP, stimulus preceding negativity, feedback related negativity, P300, source localization, heroin addiction
Record Number:CaltechAUTHORS:20171220-133552491
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20171220-133552491
Official Citation:Zhao Q, Li H, Hu B, Wu H and Liu Q (2017) Abstinent Heroin Addicts Tend to Take Risks: ERP and Source Localization. Front. Neurosci. 11:681. doi: 10.3389/fnins.2017.00681
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:83987
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:20 Dec 2017 21:53
Last Modified:03 Oct 2019 19:13

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