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Neural phase locking predicts BOLD response in human auditory cortex

Oya, Hiroyuki and Gander, Phillip E. and Petkov, Christopher I. and Adolphs, Ralph and Nourski, Kirill V. and Kawasaki, Hiroto and Howard, Matthew A. and Griffiths, Timothy D. (2018) Neural phase locking predicts BOLD response in human auditory cortex. NeuroImage, 169 . pp. 286-301. ISSN 1053-8119. http://resolver.caltech.edu/CaltechAUTHORS:20171222-094309774

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Abstract

Natural environments elicit both phase-locked and non-phase-locked neural responses to the stimulus in the brain. The interpretation of the BOLD signal to date has been based on an association of the non-phase-locked power of high-frequency local field potentials (LFPs), or the related spiking activity in single neurons or groups of neurons. Previous studies have not examined the prediction of the BOLD signal by phase-locked responses. We examined the relationship between the BOLD response and LFPs in the same nine human subjects from multiple corresponding points in the auditory cortex, using amplitude modulated pure tone stimuli of a duration to allow an analysis of phase locking of the sustained time period without contamination from the onset response. The results demonstrate that both phase locking at the modulation frequency and its harmonics, and the oscillatory power in gamma/high-gamma bands are required to predict the BOLD response. Biophysical models of BOLD signal generation in auditory cortex therefore require revision and the incorporation of both phase locking to rhythmic sensory stimuli and power changes in the ensemble neural activity.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.neuroimage.2017.12.051DOIArticle
http://www.sciencedirect.com/science/article/pii/S1053811917310753PublisherArticle
ORCID:
AuthorORCID
Adolphs, Ralph0000-0002-8053-9692
Additional Information:© 2017 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Open Access funded by National Institutes of Health. Received 18 August 2017, Revised 22 November 2017, Accepted 16 December 2017, Available online 22 December 2017. This work was supported by NIDCD (DC04290) and the Hoover fund. We thank all the members of Human Brain Research Laboratory (HRBL) at The University of Iowa, especially Haiming Chen, Matt Sutterer and Ariane Rhone for their help with conducting experiments. We thank Karl J. Friston and Nikos K. Logothetis for helpful discussion about the findings. We would like to thank the patients who contributed their time for the experiments. The authors declare no competing financial interests.
Funders:
Funding AgencyGrant Number
NIHDC04290
Hoover FundUNSPECIFIED
Subject Keywords:Neurovascular coupling; Phase locking; BOLD; Auditory cortex; Human; Broadband power; Gamma band
Record Number:CaltechAUTHORS:20171222-094309774
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20171222-094309774
Official Citation:Hiroyuki Oya, Phillip E. Gander, Christopher I. Petkov, Ralph Adolphs, Kirill V. Nourski, Hiroto Kawasaki, Matthew A. Howard, Timothy D. Griffiths, Neural phase locking predicts BOLD response in human auditory cortex, NeuroImage, Volume 169, 1 April 2018, Pages 286-301, ISSN 1053-8119, https://doi.org/10.1016/j.neuroimage.2017.12.051. (https://www.sciencedirect.com/science/article/pii/S1053811917310753)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:84020
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:22 Dec 2017 18:09
Last Modified:04 Jan 2018 19:51

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