Narasimhan, Vinayak and Lee, Jeong Oen and Du, Juan and Ndjamen, Blaise and Sretavan, David and Choo, Hyuck (2017) Black silicon as a multifunctional material for medical implants: First demonstrated use in in-vivo intraocular pressure sensing. In: 2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS). IEEE , Piscataway, NJ, pp. 387-390. ISBN 978-1-5386-2732-7. https://resolver.caltech.edu/CaltechAUTHORS:20180105-095739798
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Abstract
We report the first in vivo demonstrated use of multifunctional black silicon (b-Si) on medical implants. B-Si is integrated onto the surface of a highly miniaturized sub-mm implantable intraocular pressure (IOP) sensor. This integration has significantly improved sensor signal-to-noise ratio (SNR) through the suppression of background noise as well as durability through minimized device biofouling. The incorporation of b-Si has enabled the use of a slit-lamp, the most widely used clinical ophthalmic microscope, for real-time IOP measurements on fully awake rabbits at a world-record 12-cm readout distance. Furthermore, b-Si has shown remarkable antifouling properties during a 6-month in vivo study by minimizing tissue proliferation and encapsulation on the ocular implant, promising much improved long-term implant serviceability.
Item Type: | Book Section | ||||||||||
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Additional Information: | © 2017 IEEE. This work was funded by the National Institute of Health (NIH) (Grant No. EY024582), HMRI Investigator Award, Caltech CI2, and Powell Foundation Award. | ||||||||||
Group: | Heritage Medical Research Institute | ||||||||||
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Subject Keywords: | Black silicon, multifunctional, glaucoma, intraocular pressure, implant, antifouling | ||||||||||
Record Number: | CaltechAUTHORS:20180105-095739798 | ||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180105-095739798 | ||||||||||
Official Citation: | V. Narasimhan, J. O. Lee, J. Du, B. Ndjamen, D. Sretavan and H. Choo, "Black silicon as a multifunctional material for medical implants: First demonstrated use in in-vivo intraocular pressure sensing," 2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), Kaohsiung, 2017, pp. 387-390. doi: 10.1109/TRANSDUCERS.2017.7994068 http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7994068&isnumber=7993963 | ||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||
ID Code: | 84122 | ||||||||||
Collection: | CaltechAUTHORS | ||||||||||
Deposited By: | George Porter | ||||||||||
Deposited On: | 05 Jan 2018 21:19 | ||||||||||
Last Modified: | 03 Oct 2019 19:14 |
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