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DNA origami: The bridge from bottom to top

Xu, Anqin and Harb, John N. and Kostiainen, Mauri A. and Hughes, William L. and Woolley, Adam T. and Liu, Haitao and Gopinath, Ashwin (2017) DNA origami: The bridge from bottom to top. MRS Bulletin, 42 (12). pp. 943-950. ISSN 0883-7694. doi:10.1557/mrs.2017.275.

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Over the last decade, DNA origami has matured into one of the most powerful bottom-up nanofabrication techniques. It enables both the fabrication of nanoparticles of arbitrary two-dimensional or three-dimensional shapes, and the spatial organization of any DNA-linked nanomaterial, such as carbon nanotubes, quantum dots, or proteins at ∼5-nm resolution. While widely used within the DNA nanotechnology community, DNA origami has yet to be broadly applied in materials science and device physics, which now rely primarily on top-down nanofabrication. In this article, we first introduce DNA origami as a modular breadboard for nanomaterials and then present a brief survey of recent results demonstrating the unique capabilities created by the combination of DNA origami with existing top-down techniques. Emphasis is given to the open challenges associated with each method, and we suggest potential next steps drawing inspiration from recent work in materials science and device physics. Finally, we discuss some near-term applications made possible by the marriage of DNA origami and top-down nanofabrication.

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Additional Information:© Materials Research Society 2017. Published online: 08 December 2017. A.G. acknowledges support from the Office of Naval Research Award N000141410702, National Science Foundation Grant Nos. 1636364 and 1317694 (Expedition in Computing, Molecular Programming Project, A.T.W. acknowledges support from the NSF CMMI Grant 1562729. M.A.K. acknowledges the Academy of Finland (Project Number 308578). H.L acknowledges support from the Office of Naval Research Award N000141512520.
Funding AgencyGrant Number
Office of Naval Research (ONR)N000141410702
Academy of Finland308578
Office of Naval Research (ONR)N000141512520
Issue or Number:12
Record Number:CaltechAUTHORS:20180105-140256103
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Official Citation:Xu, A., Harb, J., Kostiainen, M., Hughes, W., Woolley, A., Liu, H., & Gopinath, A. (2017). DNA origami: The bridge from bottom to top. MRS Bulletin, 42(12), 943-950. doi:10.1557/mrs.2017.275
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:84136
Deposited By: George Porter
Deposited On:08 Jan 2018 16:14
Last Modified:15 Nov 2021 20:17

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