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Bone CLARITY reveals that anti-sclerostin antibody penetrates the lacunar canalicular system in mice under physiological loading conditions

Greenbaum, Alon and Chan, Ken and Boyce, Rogely and Salimi-Moosavi, Hossein and McBride, Helen J. and Gradinaru, Viviana (2017) Bone CLARITY reveals that anti-sclerostin antibody penetrates the lacunar canalicular system in mice under physiological loading conditions. Journal of Bone and Mineral Research, 32 (S1). S293. ISSN 0884-0431. https://resolver.caltech.edu/CaltechAUTHORS:20180108-144650592

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Abstract

Anti-sclerostin antibody (Scl-Ab) neutralizes sclerostin activity, a secreted protein from osteocytes, resulting in WNT mediated increases in bone formation and decreases in bone resorption; this dual effect on bone results in rapid increases in bone mass and strength.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/jbmr.3363DOIAbstracts
http://onlinelibrary.wiley.com/doi/10.1002/jbmr.3363/fullPublisherAbstracts
ORCID:
AuthorORCID
Gradinaru, Viviana0000-0001-5868-348X
Additional Information:© 2017 American Society for Bone and Mineral Research. First published: 28 December 2017. Disclosures: Alon Greenbaum, AMGEN, Grant/Research Support.
Funders:
Funding AgencyGrant Number
AmgenUNSPECIFIED
Issue or Number:S1
Record Number:CaltechAUTHORS:20180108-144650592
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180108-144650592
Official Citation:2017 Annual Meeting of the American Society for Bone and Mineral Research, Colorado Convention Center, Denver, CO, USA — September 8–11, 2017. J Bone Miner Res, 32: S1–S432. doi:10.1002/jbmr.3363
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:84174
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:08 Jan 2018 23:43
Last Modified:03 Oct 2019 19:15

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