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Sickle Cell Anemia, a Molecular Disease

Pauling, Linus and Itano, Harvey A. and Singer, S. J. and Wells, Ibert C. (1949) Sickle Cell Anemia, a Molecular Disease. Science, 110 (2865). pp. 543-548. ISSN 0036-8075. doi:10.1126/science.110.2865.543.

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The erythrocytes of certain individuals possess the capacity to undergo reversible changes in shape in response to changes in the partial pressure of oxygen. When the oxygen pressure is lowered, these cells change their forms from the normal biconcave disk to crescent, holly wreath, and other forms. This process is known as sickling. About 8 percent of American Negroes possess this characteristic; usually they exhibit no pathological consequences ascribable to it. These people are said to have sicklemia, or sickle cell trait. However, about 1 in 40 (4) of these individuals whose cells are capable of sickling suffer from a severe chronic anemia resulting from excessive destruction of their erythrocytes; the term sickle cell anemia is applied to their condition.

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Additional Information:© 1949 American Association for the Advancement of Science. This research was carried out with the aid of a grant from the United States Public Health Service. The authors are grateful to Professor Ray D. Owen, of the Biology Division of this Institute, for his helpful suggestions. We are indebted to Dr. Edward R. Evans, of Pasadena, Dr. Travis Winsor, of Los Angeles, and Dr. G. E. Burch, of the Tulane University School of Medicine, New Orleans, for their aid in obtaining the blood used in these experiments. Based on a paper presented at the meeting of the National Academy of Sciences in Washington, D. C., in April, 1949, and at the meeting of the American Society of Biological Chemists in Detroit in April, 1949.
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NIH Postdoctoral FellowshipUNSPECIFIED
U.S. Public Health Service (USPHS)UNSPECIFIED
National Research CouncilUNSPECIFIED
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Gates and Crellin Laboratories of Chemistry1333
Issue or Number:2865
Record Number:CaltechAUTHORS:20180111-150728139
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Official Citation:Sickle Cell Anemia, a Molecular Disease BY LINUS PAULING, HARVEY A. ITANO, S. J. SINGER, IBERT C. WELLS Science 25 Nov 1949: Vol. 110, Issue 2865, pp. 543-548 DOI: 10.1126/science.110.2865.543
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:84275
Deposited By: George Porter
Deposited On:12 Jan 2018 00:18
Last Modified:15 Nov 2021 20:18

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